通过对硝基氯苯(NCB)水解制备对硝基苯酚钠(SNP)。以SNP收率为指标,考察了碱质量分数、水油质量比、水解温度和水解时间对SNP收率的影响,筛选出对SNP收率影响较大的因素进行响应面实验,得出各因素与SNP收率之间的数学模型及最优工艺条件下的收率。结果表明,碱质量分数为10%、水油质量比为4.9、水解温度为155℃时,SNP收率最高,此时预测值为96.43%,实验值为96.52%。优化后的工艺稳定可靠,碱用量降低5%~10%,水解温度降低10~15℃,提高了生产效益。

Sodium p-nitrophenol (SNP) is prepared via the hydrolysis of p-nitrochlorobenzene (NCB),and the effects of alkali concentration,water-oil ratio,hydrolysis temperature and hydrolysis time on SNP yield are investigated.The factors that have a greater influence on SNP yield are screened out for response surface experiments.Mathematical models between each factor and SNP yield are obtained to predict the yield under optimal process conditions.It is shown by the results that SNP yield reaches the highest when the alkali concentration is 10%,the water-oil ratio is 4.9,and the hydrolysis temperature is 155℃.Under these conditions,the predicted value of SNP yield is 96.43% and the experimental one is 96.52%.The optimized process performs stable and reliable,reducing the alkali consumption by 5%-10% and the hydrolysis temperature by 10-15℃,which improves the production efficiency.

郑潘(1997-),男,硕士生,研究方向为精细有机合成,zhengpan@stu.scu.edu.cn。