研究了不同溶剂条件下三乙醇胺在不同色谱柱上的保留情况,建立了一种三乙醇胺的气相色谱-三重四极杆质谱联用检测方法。样品经溶剂超声溶解后,用0.22 μm有机滤膜过滤,供气相色谱-质谱联用检测。采用异丙醇作溶剂,DB-1701柱分离,多反应监测模式下进行检测。结果表明,三乙醇胺在0.10~1.04 mg/mL范围内线性关系良好,相关系数大于0.995 0,检出限与定量限分别为0.02、0.06 mg/mL,方法的加标回收率为91.79%~108.34%,RSD为4.98%~5.40%。本方法操作简便,快速准确,重复性好,对含三乙醇胺样品的定性检测能提供较全面的质谱参考,弥补单独气相色谱分离的不足,同时也能够满足工业样品中三乙醇胺的定量检测要求。

A novel method is developed to determine triethanolamine (TEA) in industrial samples by gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS).The retention of TEA on different chromatographic columns in different solvents is studied.The samples are dissolved under ultrasonic wave,then filtered through a 0.22 μm organic membrane,and analyzed by GC-MS/MS under multiple reaction monitoring (MRM) mode on a DB-1701 column with isopropanol as solvent.It is shown that the linear range is 0.10-1.04 mg·mL^-1 for triethanolamine,with a correlation coefficient larger than 0.995 0.The limit of detection (LOD) and limit of quantitation (LOQ) are 0.02 mg·mL^-1 and 0.06 mg·mL^-1,respectively.The spiked recoveries are 91.79%-108.34%,and relative standard deviations (RSD) is 4.98%-5.40% (n=6).It is indicated that this method is simple,rapid,accurate and reproducible.This method can provide a comprehensive reference for qualitative determination of triethanolamine samples by mass spectrometry,which makes up for the deficiency of gas chromatography,and also can meet the requirements of quantitative determination of triethanolamine in industrial samples.