以两亲性聚己内酯-聚乙二醇-聚己内酯(PCL-PEG-PCL)共聚物为载体、姜黄素类化合物为模型药,采用溶剂挥发法制备了载姜黄素(或双去甲氧基姜黄素或四氢姜黄素) PCL-PEG-PCL微球,并利用FT-IR、GPC、SEM对其进行表征,研究了其释药性和抗氧化性。结果表明,PCL-PEG-PCL微球对姜黄素、双去姜黄素和四氢姜黄素具有缓释作用;原药、载药PCL-PEG-PCL微球对ABTS·⁺、DPPH·、·OH具有较好的清除作用,且清除作用随样品浓度增加而增强。

Using amphiphilic polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) copolymer as carrier and curcumin compounds as model drugs,curcuminoids-loaded PCL-PEG-PCL microspheres are prepared via solvent evaporation method.The microspheres are characterized by FT-IR,GPC and SEM,and their drug release performance and antioxidant activity are studied.It is shown that PCL-PEG-PCL microspheres have a sustained-release effect on curcumin,bisdecurcumin and tetrahydrocurcumin.The original drug and drug-loaded PCL-PEG-PCL microspheres have good scavenging effects on ABTS·⁺,DPPH· and ·OH,and the scavenging effect strengthens with the increase of sample concentration.

蔡杰慧(1988-),女,硕士,讲师,研究方向为功能高分子材料,caijiehui2015@163.com