内酯型槐糖脂（LSL）是具有良好抗癌效果的生物表面活性剂，但其亚微乳剂型不能发挥良好的抗癌效果。制备了内酯型槐糖酯固体分散体（LSL-SD），并以载药量和溶出度为筛选标准。以醋酸纤维素（CA）为载体、药物载体质量比为1：2时，采用熔融-溶剂法制备的LSL在模拟胃液中的溶出度由45.0%提高到98.5%，证明LSL在LSL-SD中的溶出度大幅度提高。利用FT-IR、TG、DSC和SEM对样品进行表征，结果表明，LSL-SD的物理结构和表面性能被改变，药物以无定形态存在于载体中。

Lactone sophorolipids (LSL) is a kind of biosurfactant with good anti-cancer effect,but its submicron emulsion type cannot exert good anti-cancer effect.Lactone sophorolipids solid dispersion (LSL-SD) is prepared,with drug loading and dissolution as screening criteria.As cellulose acetate (CA) is used as the carrier and the drug-to-carrier ratio is 1:2,the dissolution rate of LSL that is prepared via melt-solvent method increases from 45.0% to 98.5% in simulated gastric juice,representing a greatly improved dissolution rate of LSL in LSL-SD.In addition,LSL-SD is characterized by Fourier infrared (FT-IR),thermogravimetric (TG) differential scanning calorimetry (DSC),and scanning electron microscopy (SEM).Test results all show that the physical structure and surface properties of LSL-SD have been changed,and the drug exists in an amorphous state in the carrier.