利用纳米金的光热性能及与羧甲基壳聚糖的静电吸附作用，制备了以介孔二氧化硅为载体、纳米金修饰的羧甲基壳聚糖为封堵材料的具有pH及激光响应的药物传递系统。并对激光输出功率、溶液pH、纳米金用量等条件进行优化。通过傅里叶红外光谱法、紫外-可见光谱法、透射电子显微镜等方法对合成的样品进行表征，在最优条件下检测荧光强度并确定药物释放情况。结果表明，该载药系统对药物释放有较好的pH敏感性和激光响应，在智能给药方面有良好的应用前景。

By means of the photo-thermal properties of gold nanoparticles and the electrostatic adsorption ability of carboxymethyl chitosan,a drug delivery system,which can response to pH and laser is prepared with mesoporous silica as the carrier and gold nanoparticles-modified carboxymethyl chitosan as the blocking material.The laser output power,pH value of solution,dosage of gold nanoparticles and other conditions are optimized.Fourier infrared spectroscopy,UV-Vis spectroscopy,transmission electron microscopy and other measurements are used to characterize the samples.Under the optimal conditions,the fluorescence intensity of the samples are detected and the release of drugs by the samples is also determined.The results show that this drug delivery system has a good sensitivity to pH and a good response to laser during drug release,and has a good application prospect in intelligent drug delivery.

单晓庆(1995-),女,硕士研究生,研究方向为生物功能材料的合成,1445687917@qq.com