为改善Zn作为骨缺损支架材料铸态性脆、力学强度低的缺点，以Zn作为基本研究材料，以ZnO、壳聚糖作为修饰材料，对Zn进行表面修饰，并对得到的复合材料Zn/ZnO/DOPA/CMCS进行表征。SEM、TEM及细胞外生物毒性等实验结果表明，电解沉积得到的ZnO薄膜具有良好的高度互联的规整纳米孔径，并且具有良好的孔隙率。Zn/ZnO/DOPA/CMCS增加了Zn及Zn/ZnO材料的生物相容性，减少了细胞毒性。

In order to overcome the shortcomings of zinc as a scaffold material for bone defect,such as as-cast brittleness and low mechanical strength,zinc oxide and chitosan are used as modifying materials to modify the surface of zinc and Zn/ZnO/DOPA/CMCS composite material is obtained and characterized.SEM,TEM and extracellular biological toxicity experiments show that ZnO thin films obtained by electrolytic deposition have good interconnectivity,regular nanopore diameter and good porosity.Zn/ZnO/DOPA/CMCS composite materials increase the biocompatibilities of zinc-based materials and Zn/ZnO materials,and reduce their cytotoxicity.

黄小彬(1993-),女,硕士生,研究方向为生物医药材料,1310868630@qq.com