通过功能化金纳米颗粒GSH@AuNPs的显色反应实现对Pb²⁺的简单、快速以及灵敏的可视化以及定量检测。谷胱甘肽上的巯基为谷胱甘肽活性基团，当铅离子存在时，谷胱甘肽与之结合发生配位作用。巯基捕捉铅离子，形成稳定的配位结构，使得金纳米颗粒发生团聚，颜色由酒红色变为蓝色，实现了对铅离子的检测，并且具有良好的选择性，检测灵敏度达到0.05 μmol/L。该方法简单便捷，同时实现了对实际样品水样中铅离子的检测。

In this paper,a simple,fast and sensitive visualized and quantitative detection for Pb²⁺ is realized through the color change of the functionalized gold nanoparticle GSH@AuNPs.The -SH group is the active group on glutathione.There will be a coordination reaction between glutathione and Pb²⁺ in the presence of Pb²⁺.The -SH can capture Pb²⁺ to form a stable coordination structure,which induces GSH@AuNPs to aggregate,reflecting with a color change from claret to blue.The detection to Pb²⁺ with the detection limit of 0.05 μmol·L^-1 is therefore realized.This method is simple and convenient,and can achieve the detection of Pb²⁺ in lake water sample.