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摘要
采用真空间歇精馏法实现了α-紫罗兰酮和β-紫罗兰酮异构体混合物的分离，考察了原料液组成、回流比、塔顶采出率、塔釜加热温度、塔节保温温度对异构体分离的影响，同时探讨了精馏操作时间对产品质量的影响。结果表明，在适宜的精馏操作条件下，塔釜产品β-紫罗兰酮的质量分数高于96%，同时收率能保持在90%以上，满足医药中间体应用要求。
Abstract
α-Ionone and β-ionone are separated by vacuum batch distillation.The effects of raw material composition,reflux ratio,recovery ratio at the top of the tower,tower kettle heating temperature and tower section heat preservation temperature on isomers separation are investigated.Moreover,the influences of distillation operation time on product quality are also studied.The results show that under the moderate distillation operating conditions,the mass fraction of β-ionone in the tower kettle is higher than 96%,and the yield remains above 90%,meeting the requirements of pharmaceutical intermediates.
关键词
紫罗兰酮
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分离
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间歇精馏
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真空
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异构体
Key words
ionone
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separation
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batch distillation
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vacuum
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isomers
Author summay
真空间歇精馏法分离紫罗兰酮异构体[J].
现代化工, 2017, 37(12): 160-163 DOI:10.16606/j.cnki.issn0253-4320.2017.12.038
