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现代化工  2022, Vol. 42 Issue (11): 256-260    DOI: 10.16606/j.cnki.issn0253-4320.2022.11.048
  分析测试 本期目录 | 过刊浏览 | 高级检索 |
丹参酮ⅡA磺酸钠的电化学测定及与DNA作用的研究
孙章华1, 陈美凤2, 马心英2, 秦佳濛2, 薛守庆2
1. 山东省菏泽生态环境监测中心, 山东 菏泽 274000;
2. 菏泽学院化学化工学院, 山东 菏泽 274000
Electrochemical determination of sodium tanshinone ⅡA sulfonate and its effect on DNA
SUN Zhang-hua1, CHEN Mei-feng2, MA Xin-ying2, QIN Jia-meng2, XUE Shou-qing2
1. Shandong Heze Ecology and Environment Monitoring Center, Heze 274000, China;
2. College of Chemistry and Chemical Engineering, Heze University, Heze 274000, China
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摘要 制备了聚L-亮氨酸修饰玻碳电极,并对丹参酮ⅡA磺酸钠进行测定。结果表明,在此修饰电极上聚L-亮氨酸催化了丹参酮ⅡA磺酸钠电化学氧化还原反应。实验对该电极的制备条件以及测试条件进行了优化。丹参酮ⅡA磺酸钠的氧化峰电流与浓度呈线性关系,该修饰电极具有良好的灵敏度、选择性和稳定性,可用于相关产品的生产及质量控制。另外,用电化学和紫外分光光度法分别研究了丹参酮ⅡA磺酸钠和DNA的相互作用。结果表明,丹参酮ⅡA磺酸钠和dsDNA发生了明显的相互作用。
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孙章华
陈美凤
马心英
秦佳濛
薛守庆
关键词:  L-亮氨酸  玻碳电极  丹参酮ⅡA磺酸钠    
Abstract: Poly(L-leucine) modified glassy carbon electrode is prepared,and used to determine sodium tanshinone ⅡA sulfonate.The results show that poly(L-leucine) catalyzes the electrochemical redox reactions of sodium tanshinone ⅡA sulfonate on the modified electrode.The preparation and testing conditions for the electrode are optimized.The oxidation peak current of sodium tanshinone ⅡA sulfonate shows linear with its concentration.This modified electrode has good sensitivity,selectivity and stability,and can be used for the production and quality control of related products.In addition,the interaction between sodium tanshinone ⅡA sulfonate and DNA is studied by means of electrochemistry and UV spectrophotometry,respectively.It is shown that there is obvious interaction between sodium tanshinone ⅡA sulfonate and dsDNA.
Key words:  L-leucine    glassy carbon electrode    sodium tanshinone ⅡA sulfonate
收稿日期:  2021-12-14      修回日期:  2022-08-23           出版日期:  2022-11-20
ZTFLH:  R927.2  
基金资助: 山东省高等学校科技计划项目(J17KB62)
通讯作者:  薛守庆(1984-),男,硕士,讲师,从事分析与材料合成工艺的研究,通讯联系人,dhxxsq@163.com。    E-mail:  dhxxsq@163.com
作者简介:  孙章华(1977-),男,硕士,高级工程师,从事环境监测和药物分析方法的研究,szh3699@163.com
引用本文:    
孙章华, 陈美凤, 马心英, 秦佳濛, 薛守庆. 丹参酮ⅡA磺酸钠的电化学测定及与DNA作用的研究[J]. 现代化工, 2022, 42(11): 256-260.
SUN Zhang-hua, CHEN Mei-feng, MA Xin-ying, QIN Jia-meng, XUE Shou-qing. Electrochemical determination of sodium tanshinone ⅡA sulfonate and its effect on DNA. Modern Chemical Industry, 2022, 42(11): 256-260.
链接本文:  
https://www.xdhg.com.cn/CN/10.16606/j.cnki.issn0253-4320.2022.11.048  或          https://www.xdhg.com.cn/CN/Y2022/V42/I11/256
[1] Yu M L, Li S M, Gao X, et al.Sodium tanshinoneⅡA sulfonate for coronary heart disease:A systematic review of randomized controlled trials[J].Chin J Integr Med, 2020, 26(3):219-226.
[2] 许何丽, 张新生, 谭宏友, 等.丹参酮ⅡA磺酸钠注射液对亚砷酸钠导致的H9c2心肌细胞损伤的影响[J].中国医科大学学报, 2021, 50(4), 332-335.
[3] 马晓聪, 李建橡, 许明东, 等.丹参酮ⅡA磺酸钠注射液治疗不稳定型心绞痛疗效和安全性的Meta[J].世界科学技术-中医药现代化, 2015, 17(9):1766-1774.
[4] Chen T T, Li M L, Fan X H, et al.Sodium tanshinoneⅡA sulfonate prevents angiotensinⅡ-induced differentiation of human atrial fibroblasts into myofibroblasts[J].Oxid Med Cell Longev, 2018, 24:1-10.
[5] Hao G, Wang N, Cui J, et al.Determination of sodium tanshinone ⅡA sulfonate inplasma by liquid hromatography-electrosprayionisation-tandemmasss pectrometry[J].Biomed Chromatogr, 2007, 21:1172-1179.
[6] Tan D, Wu J R, Zhang X M, et al.Sodium tanshinone ⅡA sulfonate injection as adjuvant treatment for unstable angina pectoris:A meta-analysis of 17 randomized controlled trials[J].Chin J Integr Med, 2018, 24(2):156-160.
[7] Shang Q, Xu H, Huang L.Tanshinone ⅡA:A promising natural cardioprotective agent[J].Evid Based Complement Alternat Med 2012, 2012:716459.
[8] Chen Z, Xu H.Anti-inflammatory and immunomodulatory mechanism of tanshinone ⅡA for atherosclerosis[J].Evid Based Complement Alternat Med, 2014:2014:267976.
[9] Mao S, Jin H, Bi Y, et al.Ion-pairreversed-phase HPLC method fordetermination of sodium tanshinone ⅡA sulfonate inbiological samples andi ts pharmacokinetics and biodistributionin mice[J].Chem Pharm Bull (Tokyo), 2007, 55:753-756.
[10] Mao S J, Hou S X, Liang Z, et al.Ion-pairreversed-phase HPLC:As sayvalidation ofsodium tanshinone ⅡA sulfonatein mouse plasma[J].J Chromatogr B:Anal Technol Biomed Life Sci, 2006, 831:163-168.
[11] Mao S J, Jin H, Bi Y Q, et al.Ion-pair reversed-phase HPLC method for determination of sodium tanshinone ⅡA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice[J].Chemical & Pharmaceutical Bulletin, 2007, 55(5):753-756.
[12] Hao H, Wang G, Cui N, et al.Determination of sodium tanshinone ⅡA sulfonate inplasma by liquid chromatography-electrospray ionisation-tandem massspectrometry[J].Biomed Chromatogr, 2007, 21(11):1172-1179.
[13] He T T, Zou Q G, Feng Z B, et al.Study of sodium tanshinone ⅡA sulfonate tissue distribution in rat by liquid chromatography/tandem mass spectrometry[J].Arzneimittelforschung, 2010, 60(11):660-666.
[14] Qin W W, Wang B, Pei Xiao, et al.Determination of sodium tanshinone ⅡA sulfonate in human plasma by LC-MS/MS and its application to a clinical pharmacokinetic study[J].Journal of Pharmaceutical & Biomedical Analysis, 2016, 121:204-208.
[15] Sunil T S, KumarNaik B E, Kumara Swamy, et al.Poly(L-leucine) modified carbon paste electrode as an electrochemical sensor for the detection of paracetamol in presence of folic acid[J].Materials Science for Energy Technologies, 2020, 3:626-632.
[16] Zheng X, Guo Y, Zheng J, et al.Simultaneous determination of ascorbic acid, dopamine and uric acid using poly(L-leucine)/DNA composite film modified electrode[J].Sensors & Actuators B Chemical, 2015, 213:188-194.
[17] Monnappa A B, Manjunatha J, Bhatt A S, et al.Fabrication of a sensitive and selective electrochemical sensing platform based on poly-l-leucine modified sensor for enhanced voltammetric determination of Riboflavin[J].Journal of Food Measurement and Characterization, 2020, 14(4):3633-3643.
[18] Karimi-Maleh H, Tahernejad-Javazmi F, Atar N, et al.A novel DNA biosensor based on a pencil graphite electrode modified with polypyrrole/functionalized multiwalled carbon nanotubes for determination of 6-mercaptopurine anticancer drug[J].Industrial & Engineering Chemistry Research, 2015, 54(14):3634-3639.
[19] Chen M F, Ma X Y, Xia L, et al.Study of DNA-diethylstilboestrol interaction using graphene-based thin-film sensor and UV-Vis spectroscopy[J].Journal of the Chilean Chemical Society, 2018, 63(1):3795-3798.
[20] 郭英, 贝玉祥, 高云涛.灯盏花素与DNA相互作用的电化学及吸收光谱[J].应用化学, 2009, 26(9):1045-1049.
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