Preparation of mesoporous silica drug-loading microspheres with dual response to pH/temperature and study on their slow-release properties
GE Yong-chi1, LIU Zhen-yu1, CUI Bao-rong1, SHANG Hong-zhou2, SUN Xiao-ran1, JIANG Yue1, WANG Zi-meng3
1. College of Chemical Engineering, North China University of Science and Technology, Tangshan 063210, China; 2. College of Material Science and Engineering, North China University of Science and Technology, Tangshan 063210, China; 3. School of Pharmacy, North China University of Science and Technology, Tangshan 063210, China
Abstract: Mesoporous silica microspheres (mSiO2) are prepared by sol-gel method,and is modified functionally by graft copolymer among carboxymethyl chitosan (CMCS),N-isopropylacrylamide (NIPAM) and acrylamide (AM) to prepare mesoporous silica drug carrier (mSiO2@CMCS/NIPAM/AM) with dual response to pH and temperature.The structure and properties of the drug carrier are analyzed by SEM,TM and FT-IR.It is verified that the equilibrium adsorption capacity of doxorubicin hydrochloride is 94.99 mg·g-1,the drug loading rate reaches 9.05% and the entrapment efficiency reaches 66.59% when doxorubicin hydrochloride is used as the model drug and pH is 7.The cumulative release rate of doxorubicin hydrochloride reaches 71% at pH=5.7 and 43℃.
葛永驰, 刘振宇, 崔宝蓉, 尚宏周, 孙晓然, 江悦, 王子萌. pH/温度双重响应型介孔二氧化硅载药微球的制备及缓释性能研究[J]. 现代化工, 2022, 42(11): 155-160,169.
GE Yong-chi, LIU Zhen-yu, CUI Bao-rong, SHANG Hong-zhou, SUN Xiao-ran, JIANG Yue, WANG Zi-meng. Preparation of mesoporous silica drug-loading microspheres with dual response to pH/temperature and study on their slow-release properties. Modern Chemical Industry, 2022, 42(11): 155-160,169.
[1] 刘宗超, 李哲轩, 张阳, 等.2020全球癌症统计报告解读[J].肿瘤综合治疗电子杂志, 2021, 7(2):1-14. [2] 马博乐, 陈雨晴, 祝星宇, 等.介孔二氧化硅纳米粒的功能化修饰及其在药物研究中的应用[J].中国药房, 2018, 29(15):2156-2160. [3] Maria V Liberti, Jason W Locasale.Correction to:'the warburg effect:How does it benefit cancer cells'[J].Trends in Biochemical Sciences Volume, 2016, 3(41):287-287. [4] Marion S, Paul M J McSheehy, John R Griffiths, et al.Causes and consequences of tumour acidity and implications for treatment[J].Molecular Medicine Today, 2000, 6(1):15-19. [5] 王汉杰.多功能高分子脂质体的制备及在药物载体方面的应用[D].天津:天津大学, 2012. [6] 段伟华.智能响应的药物运输仓-酯酶响应性多肽纳米胶束[D].青岛:青岛科技大学, 2020. [7] 王培鑫.聚乙烯醇复合水凝胶的制备及其缓释性能的研究[D].杭州:浙江工业大学, 2020. [8] 史进进.以碳纳米材料为载体的肿瘤靶向给药系统的研究[D].郑州:郑州大学, 2014. [9] 张婷婷.功能化磁性纳米材料的合成及其载药性能研究[D].宁波:宁波大学, 2019. [10] 顾颂恩.靶向循环肿瘤细胞介孔二氧化硅纳米药物载体的构建及其抑制肿瘤转移作用研究[D].福州:福州大学, 2015. [11] Vallet-Regi M, Ramila A, Del Real R P, et al.A new property of MCM-41:Drug delivery system[J].Chemistry of Materials, 2001, 2(13):308-311. [12] Tang F, Li L, Chen D.Mesoporous silica nanoparticles:Synthesis, biocompatibility and drug delivery[J].Advanced Materials, 2012, 12(24):1504-1534. [13] Yang Y, Yu C.Advances in silica-based nanoparticles for targeted cancer therapy, nanomedicine nanotechnology[J].Biology and Medicine, 2016, 2(12):317-332. [14] Agotegaray M A, Lassalle V L.Silica-coated magnetic nanoparticles:An insight into targeted drug delivery and toxicology[M].Berlin:Springer, 2017. [15] Macquarrie D J.Direct preparation of organically modified MCM-type materials.Preparation and characterisation of aminopropyl[J].Chemical Communications, 1996, 16(16):1961-1962. [16] Zhang X, Huang N, Wang G, et al.Synthesis of highly loaded and well dispersed Cu O/SBA-15 via an ultrasonic post-grafting method and its application as a catalyst for the direct hydroxylation of benzene to phenol[J].Microporous & Mesoporous Materials, 2013, 177(177):47-53.
