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现代化工  2022, Vol. 42 Issue (9): 125-128,133    DOI: 10.16606/j.cnki.issn0253-4320.2022.09.025
  科研与开发 本期目录 | 过刊浏览 | 高级检索 |
两亲性胶束包覆Eu3+掺杂LDHs纳米载体材料的制备与性能研究
梁良1, 任锦2, 余敬谋3, 石向群1, 余霞1
1. 九江学院实验中心, 江西 九江 332005;
2. 九江学院药学与生命科学学院, 江西 九江 332005;
3. 湖州师范学院生命科学学院, 浙江 湖州 313000
Preparation and properties of Eu3+-doped LDHs nano carrier materials coated by amphiphilic micelles
LIANG Liang1, REN Jin2, YU Jing-mou3, SHI Xiang-qun1, YU Xia1
1. Lab Center, Jiujiang University, Jiujiang 332005, China;
2. School of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332005, China;
3. College of Life Sciences, Huzhou University, Huzhou 313000, China
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摘要 采用两亲性胶束CSA-ss-DOCA(CsD)对Eu3+掺杂层状双氢氧化物Eu-LDH(LE)进行包覆,制备得到纳米载体材料LE@CsD。利用荧光光谱、FT-IR、XRD、TG、粒度以及溶血实验和蛋白吸附等方法对样品结构、尺寸、热力学性质与生物相容性进行表征。结果表明,LE@CsD在613 nm处(λex=306 nm)具有Eu3+的特征荧光,CsD对LE的包覆并未影响样品获得荧光特性;模板药物分子五氟尿嘧啶(5Fu)被成功负载到LE@CsD上,且其层状结构未受破坏,验证了样品的载体性质;负电性胶束CsD通过静电作用与LE结合,"屏蔽"了LE层板的正电荷,使LE@CsD的蛋白吸附率仅为0.05%,溶血率低至1.16%,平均粒径控制为(230.3±2.7) nm,具备良好的生物相容性。
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梁良
任锦
余敬谋
石向群
余霞
关键词:  层状双氢氧化物  胶束  载体  荧光  生物相容性    
Abstract: LE@CsD,a kind of nano carrier material,is prepared by using amphiphilic micelles CSA-ss-DOCA to coat Eu3+-doped layered double hydroxides (Eu-LDH,or LE).The structure,size,thermodynamic properties and biocompatibility of the samples are investigated by means of fluorescence spectra,FT-IR,XRD,TG,particle size analyzer,hemolysis test and protein adsorption.The results indicate that LE@CsD has a characteristic fluorescence of Eu3+ at 613 nm (λex=306 nm),and the fluorescence characteristics of the sample is not affected by the coating of LE by CsD;Pentafluorouracil (5Fu),the template drug molecule,is successfully loaded onto LE@CsD,and its layered structure has not been damaged,verifying the carrier properties of the sample;CsD negative micelles combines with LE through electrostatic action to "shield" the positive charge of LE laminate,which makes the protein adsorption rate as low as 0.05%,the hemolysis rate as low as 1.16%,and the average particle size be controlled at 230.3±2.7 nm.LE@CsD also has a good biocompatibility.
Key words:  layered double hydroxides    micelles    carrier    fluorescence    biocompatibility
收稿日期:  2021-09-29      修回日期:  2022-06-30           出版日期:  2022-09-20
ZTFLH:  O614  
  TB33  
基金资助: 江西省卫健委科技项目(20201118);国家自然科学基金项目(81860631)
通讯作者:  任锦(1986-),女,博士,讲师,研究方向为药物递送体系的研究与开发,通讯联系人,yanjiushengrj@126.com    E-mail:  yanjiushengrj@126.com
作者简介:  梁良(1986-),男,硕士,实验师,主要从事纳米药物载体材料研究,liangliangrj@126.com
引用本文:    
梁良, 任锦, 余敬谋, 石向群, 余霞. 两亲性胶束包覆Eu3+掺杂LDHs纳米载体材料的制备与性能研究[J]. 现代化工, 2022, 42(9): 125-128,133.
LIANG Liang, REN Jin, YU Jing-mou, SHI Xiang-qun, YU Xia. Preparation and properties of Eu3+-doped LDHs nano carrier materials coated by amphiphilic micelles. Modern Chemical Industry, 2022, 42(9): 125-128,133.
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https://www.xdhg.com.cn/CN/10.16606/j.cnki.issn0253-4320.2022.09.025  或          https://www.xdhg.com.cn/CN/Y2022/V42/I9/125
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