Abstract: Ceramic membrane technology is applied in the ethanol dialysis of lipophilic lipstatin from fermentation broth.Based on permeation flux of ceramic membrane and ethanol consumption,the basic parameters and methods for extraction of lipstatin are determined as follows:the pore size of ceramic membrane is 50 nm,membrane surface velocity is 5 m·s-1,the average transmembrane pressure is 0.1 MPa,95% ethanol begins to feed continuously when the fermentation broth is concentrated to 2 times,the feeding speed of ethanol is consistent with the permeation flux to maintain a constant level in the circulating fermentation tank,the collection of permeation broth is started when the content of ethanol in permeation broth reaches 55%,total ethanol consumption are 2 times.After these operations,the recovery yield of lipstatin reaches 95%,which can meet the production specifications.The technique to control the average transmembrane pressure can significantly enhance the permeation flux of lipstatin extraction,which provides ideas for further enhancing the permeation flux of ceramic membrane and expanding its application scope.
郭远良, 黄炽, 侯红波, 彭滢. 陶瓷膜在奥利司他中间体利普斯他汀提取中的应用[J]. 现代化工, 2022, 42(3): 174-177.
GUO Yuan-liang, HUANG Chi, HOU Hong-bo, PENG Ying. Application of ceramic membrane in extraction of lipstatin, an intermediate of orlistat. Modern Chemical Industry, 2022, 42(3): 174-177.
