Abstract: Global current situation about production of polyhydroxyalkanoates (PHAs) by means of microorganisms is introduced.Research situation about PHAs production by microbial fermentation using different carbon sources are systematically reviewed,compared,and analyzed.The future development trends and key research directions for the carbon sources used for PHAs production by microbial fermentation are envisaged.
项兰, 翁庆北, 周桂雄. 利用廉价碳源发酵生产聚羟基脂肪酸酯(PHAs)的研究进展[J]. 现代化工, 2022, 42(3): 64-68,73.
XIANG Lan, WENG Qing-bei, ZHOU Gui-xiong. Research progress in production of polyhydroxyalkanoates by fermentation of low-cost carbon sources. Modern Chemical Industry, 2022, 42(3): 64-68,73.
[1] 李祖义.生物塑料引领塑料产业新方向[J].工业微生物,2019,49(4):56-63. [2] Ong S Y,Zainab L I,Pyary S,et al.A novel biological recovery approach for PHA employing selective digestion of bacterial biomass in animals[J].Appl Microbiol Biotechnol,2018,102(5):2117-2127. [3] 邱石正,李佳益,杨景辰,等.低成本合成聚羟基脂肪酸酯(PHAs)的研究进展[J].生物技术通报,2019,35(9):45-52. [4] Thomas T,Sudesh K,Bazire A,et al.PHA production and PHA synthases of the Halophilic Bacterium Halomonas sp.SF2003[J].Bioengineering,2020,7(1):29. [5] Jung H R,Yang S Y,Moon Y M,et al.Construction of efficient platform Escherichia coli Strains for polyhydroxyalkanoate production by Engineering Branched Pathway[J].Polymers:Basel,2019,11(3):509. [6] Saranya V,Rajeswari V,Abirami P,et al.Statistical media design for efficient polyhydroxyalkanoate production in Pseudomonas sp.MNNG-S[J].Preparative Biochemistry and Biotechnology,2016,46(5):446-453. [7] Sohn Y J,Kim H T,Baritugo K A,et al.Biosynthesis of polyhydroxyalkanoates from sucrose by metabolically engineered Escherichia coli strains[J].International Journal of Biological Macromolecules,2020,149:593-599. [8] Bhatia S K,Yoon J J,Kim H J,et al.Engineering of artificial microbial consortia of Ralstonia eutropha and Bacillus subtilis for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer production from sugarcane sugar without precursor feeding[J].Bioresource Technology,2018,257:92-101. [9] Page W J.Production of polyhydroxyalkanoates by Azotobacter vinelandii UWD in beet molasses culture[J].Fems Microbiology Letters,1992:149-157. [10] Evangeline S,Sridharan T B.Biosynthesis and statistical optimization of polyhydroxyalkanoate (PHA) produced by Bacillus cereus VIT-SSR1 and fabrication of biopolymer films for sustained drug release[J].International Journal of Biological Macromolecules,2019,135:945-958. [11] Gahlawat G,Srivastava A K.Model-based nutrient feeding strategies for the increased production of polyhydroxybutyrate (PHB) by Alcaligenes latus[J].Appl Biochem Biotechnol,2017,183(2):530-542. [12] Pais J,Farinha I,Freitas F,et al.Improvement on the yield of polyhydroxyalkanotes production from cheese whey by a recombinant Escherichia coli strain using the proton suicide methodology[J].Enzyme & Microbial Technology,2014,55:151-158. [13] Karray F,Abdallah M B,Baccar N,et al.Production of Poly(3-Hydroxybutyrate) by Haloarcula,Halorubrum,and Natrinema Haloarchaeal genera using starch as a carbon source[J].Archaea (Vancouver,B.C.),2021,2021(1034):1-10. [14] Ali I,Jamil N.Biosynthesis and characterization of poly-3-hydroxyalkanote (PHA) from newly isolated bacterium Bacillus sp.AZR-1[J].Ranian Journal of Science & Technology,2018,42(2):371-378. [15] Israni N,Shivakumar S.Polyhydroxyalkanoate (PHA) biosynthesis from directly valorized ragi husk and sesame oil cake by Bacillus megaterium strain Ti3:statistical optimization and characterization[J].International Journal of Biological Macromolecules,2020,148:20-30. [16] Thuoc D V,Anh V T M.Bioconversion of crude fish oil into poly-3-hydroxybutyrate by Ralstonia sp.M91[J].Applied Biochemistry and Microbiology,2021,57(2):219-225. [17] Kamilah H,Al-Gheeti A,Yang T A,et al.The use of palm oil-based waste cooking oil to enhance the production of polyhydroxybutyrate [P(3HB)] by Cupriavidus necator H16 Strain[J].Arabian Journal For Science And Engineering,2018,43(7):3453-3463. [18] Volova T,Demidenko A,Kiselev E,et al.Polyhydroxyalkanoate synthesis based on glycerol and implementation of the process under conditions of pilot production[J].Appl Microbiol Biotechnol,2019,103(1):225-237. [19] Pan C,Tan G A,Ge L,et al.Two-stage microbial conversion of crude glycerol to 1,3-propanediol and polyhydroxyalkanoates after pretreatment[J].Journal of Environmental Management,2019,232:615-624. [20] Singh S,Sithole B,Lekha P,et al.Optimization of cultivation medium and cyclic fed-batch fermentation strategy for enhanced polyhydroxyalkanoate production by Bacillus thuringiensis using a glucose-rich hydrolyzate[J].Bioresources and Bioprocessing,2021,8(1):1-17. [21] Liu C,Wang X,Yang H,et al.Biodegradable polyhydroxyalkanoates production from wheat straw by recombinant Halomonas elongata A1[J].International Journal of Biological Macromolecules,2021,187(7):675-682. [22] Fang F,Xu R,Huang Y,et al.Production of polyhydroxyalkanoates and enrichment of associated microbes in bioreactors fed with rice winery wastewater at various organic loading rates[J].Bioresource Technology,2019,292:121978. [23] Tamang P,Banerjee R,Koster S,et al.Comparative study of polyhydroxyalkanoates production from acidified and anaerobically treated brewery wastewater using enriched mixed microbial culture[J].Journal of Environmental Science,2019,78(4):139-148.