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现代化工  2022, Vol. 42 Issue (1): 189-194    DOI: 10.16606/j.cnki.issn0253-4320.2022.01.038
  科研与开发 本期目录 | 过刊浏览 | 高级检索 |
二硫化钼纳米花球负载阿霉素对癌细胞的光热-化疗协同治疗作用
廉爽1, 卢淇月1, 章寅2, 谢文娟1, 蒋东丽1
1. 桂林医学院药学院, 广西 桂林 541100;
2. 安徽工业大学化学与化工学院, 安徽 马鞍山 243002
Photothermal-chemotherapy synergistic therapy effect of molybdenum disulfide flower-like nanospheres loaded doxorubicin on cancer cells
LIAN Shuang1, LU Qi-yue1, ZHANG Yin2, XIE Wen-juan1, JIANG Dong-li1
1. Pharmacy School, Guilin Medical University, Guilin 541100, China;
2. School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243002, China
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摘要 以钼酸钠、硫脲、柠檬酸及PEG-400为原料,通过水热法制备纳米MoS2,考察了材料的光热转换性能及其对阿霉素(DOX)的负载及控释性能,并探讨了该载药体系对癌细胞的光热-化疗协同治疗作用。结果表明,通过该水热反应体系制备的尺寸约500 nm花球状MoS2纳米材料具有良好的光热转换性能,对DOX的负载率可以达到136.8%,且其释药行为具有pH响应性,pH=5.8时DOX的累积释放量达到70.29%,约为pH=7.4条件下的7倍,表明该材料在药物负载/控释方面具有一定应用价值。此外,负载DOX后的MoS2-DOX的纳米复合物在近红外光照射下对肝癌细胞HuH-7的抑制率高达92.09%,抑制效果明显高于单一的光热治疗和化疗。
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廉爽
卢淇月
章寅
谢文娟
蒋东丽
关键词:  二硫化钼  纳米花球  水热合成  载药  光热-化疗协同治疗    
Abstract: Flower-like MoS2 nanospheres are prepared via hydrothermal method by using sodium molybdate,thiourea,citric acid and PEG-400 as raw materials.The photothermal conversion performance of MoS2 nanospheres is studied,and the loading and controlled release ability of the nanospheres to doxorubicin (DOX) are evaluated.Photothermal-chemotherapy synergistic therapy effect of the drug delivery system on cancer cells is further explored.It is shown that the as-prepared flower-like MoS2 nanospheres with a size about 500 nm exhibit excellent photothermal effect.As a carrier,the load rate of the nanospheres to DOX can reach 136.8%,and the drug release behavior shows responsive to pH.As pH=5.8,the cumulative release amount of DOX can reach 70.29%,which is about 7 times of that at pH=7.4,indicating that the material has promising application in drug loading/controlled release.In addition,MoS2-DOX composites under near infrared laser irradiation can reach 92.09% of inhibition rate to HuH-7 liver cancer cells,which is significantly higher than that of photothermal therapy alone or chemotherapy alone.
Key words:  molybdenum disulfide    flower-like nanospheres    hydrothermal synthesis    drug loading    synergistic therapy of photothermal and chemotherapy
收稿日期:  2021-08-05      修回日期:  2021-11-06           出版日期:  2022-01-20
ZTFLH:  O611.4  
基金资助: 桂林医学院博士科研启动基金(31304018001);大学生创新创业训练计划项目(201910601035);国家自然科学基金(61971003)
通讯作者:  蒋东丽(1977-),女,博士,副教授,研究方向为纳米生物医用材料及纳米无机气敏材料,通讯联系人,auqfai@glmc.edu.cn。    E-mail:  auqfai@glmc.edu.cn
作者简介:  廉爽(1998-),女,硕士研究生,研究方向为纳米生物医用材料,2587063618@qq.com
引用本文:    
廉爽, 卢淇月, 章寅, 谢文娟, 蒋东丽. 二硫化钼纳米花球负载阿霉素对癌细胞的光热-化疗协同治疗作用[J]. 现代化工, 2022, 42(1): 189-194.
LIAN Shuang, LU Qi-yue, ZHANG Yin, XIE Wen-juan, JIANG Dong-li. Photothermal-chemotherapy synergistic therapy effect of molybdenum disulfide flower-like nanospheres loaded doxorubicin on cancer cells. Modern Chemical Industry, 2022, 42(1): 189-194.
链接本文:  
https://www.xdhg.com.cn/CN/10.16606/j.cnki.issn0253-4320.2022.01.038  或          https://www.xdhg.com.cn/CN/Y2022/V42/I1/189
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