Continuous flow process for synthesis of 3,4-dichloronitrobenzene from o-dichlorobenzene
MA Kai-xuan1,2, ZHANG Yue2, YAN Sheng-hu1,2, LIU Jian-wu1,2, SHEN Jie-fa1,2, MA Xiao-ming1,2, GU Shun-lin1,2, CHEN Dai-xiang1,2
1. School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China; 2. Continuous Flow Engineering Laboratory of National Petroleum and Chemical Industry, Changzhou 213164, China
Abstract: The continuous flow process for synthesizing 3,4-dichloronitrobenzene in pulse mixed structure microchannel reactor is studied by using o-dichlorobenzene as raw material,nitric acid as nitrating agent and concentrated sulfuric acid as solvent.Through studying the molar ratio of reactive materials,the molar ratio of nitric acid to sulfuric acid,the reaction temperature,the residence time etc.,the optimum process conditions are obtained as follows:n(o-dichlorobenzene):n(nitric acid):n(sulfuric acid)=1:2:4,the reaction system temperature is at 60℃,and the residence time is 135 s.This process fully utilizes the excellent mass transfer and heat transfer characteristics of the microchannel reactor,greatly shortens the reaction time,increases the reaction rate,expands the selection interval of the process conditions,realizes effective control of the reaction process,and increases the safety factor.
马凯旋, 张跃, 严生虎, 刘建武, 沈介发, 马晓明, 辜顺林, 陈代祥. 邻二氯苯合成3,4-二氯硝基苯的连续流工艺研究[J]. 现代化工, 2020, 40(8): 154-157.
MA Kai-xuan, ZHANG Yue, YAN Sheng-hu, LIU Jian-wu, SHEN Jie-fa, MA Xiao-ming, GU Shun-lin, CHEN Dai-xiang. Continuous flow process for synthesis of 3,4-dichloronitrobenzene from o-dichlorobenzene. Modern Chemical Industry, 2020, 40(8): 154-157.
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