Abstract: Effects of Biginelli reaction over D001×7 resin and several common catalysts are compared.The conditions of Biginelli reaction catalyzed by D001×7 resin are optimized.It is shown that the yield is as high as 92.8% when D001×7 resin is used as catalyst,ethanol is used as solvent,the adding amount of catalyst is 0.02 g/(1 mmoL aldehyde) and reaction lasts for 2 h with reflux at 80℃.The yield can still maintain at 83.6% after the catalyst is used repeatedly for 4 times.Through optimizing reaction conditions,a series of 3,4-dihydropyrimidin-2(1H)-ones derivatives are synthesized,and all products are characterized and confirmed by melting point,1HNMR and IR.
蒋卫华, 滕巧巧, 孟启, 陶永新. 树脂D001×7绿色催化Biginelli反应一锅合成3,4-二氢嘧啶-2-酮类化合物的研究[J]. 现代化工, 2020, 40(5): 90-94.
JIANG Wei-hua, TENG Qiao-qiao, MENG Qi, TAO Yong-xin. One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones over D001×7 resin via Biginelli reaction. Modern Chemical Industry, 2020, 40(5): 90-94.
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