Research progress on extraction of solanesol from tobacco
ZHAO Guo-jie1,2, LIU Jia-lei2, ZHANG Shao-feng1, ZHANG Ji2, YANG Lu-wei2
1. School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, China; 2. Beijing Key Laboratory of Thermal Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Abstract: Starting with the extraction and purification of solanesol,the pretreatment of tobacco,and the extraction method,saponification process and purification method for solanesol are briefly reviewed.The analysis shows that the pretreatment of tobacco is beneficial to subsequent separation and purification,and ammonia leaching pretreatment can also have saponification effect and improve extraction rate.Compared with traditional solvent extraction method,the ultrasonic extraction,microwave-assisted extraction and supercritical CO2 extraction methods all exhibit a higher extraction rate and much shorter extraction time.Dynamic saponification is more effective than traditional saponification.More importantly,it reduces saponification time to prevent solanesol from being exposed to alkaline environment for a long time.Solanesol separated by the polymer co-precipitation technology can meet the requirements of synthesizing coenzyme Q10,showing the advantages of small investment and easy operation.Nowadays,the synthesis of molecularly imprinted polymers with better adsorption effect is an important research direction.
赵国杰, 刘家磊, 张少峰, 张骥, 杨鲁伟. 烟草中茄尼醇的提取研究进展[J]. 现代化工, 2019, 39(S1): 79-84,88.
ZHAO Guo-jie, LIU Jia-lei, ZHANG Shao-feng, ZHANG Ji, YANG Lu-wei. Research progress on extraction of solanesol from tobacco. Modern Chemical Industry, 2019, 39(S1): 79-84,88.
[1] Zi W H,Peng J H,Zhang X L,et al.Optimization of waste tobacco stem expansion by microwave radiation for biomass material using response surface methodology[J].Journal of the Taiwan Institute of Chemical Engineers,2013,44(4):678-685. [2] Xiang D H,Yao Z M,Liu Y H,et al.Analysis on solanesol content and genetic diversity of chinese flue-cured tobacco (Nicotiana tabacum L.)[J].Crop Science,2017,57(2):847-855. [3] Severson R F,Ellington J J,Schlotzhauer P F,et al.Gas chromatographic method for the determination of free and total solanesol in tobacco[J].Journal of Chromatography,1977,139(2):269-282. [4] Zhao C J,Zu Y G,Li C Y.Distribution of solanesol in nicotiana tabacum[J].Journal of Forestry Research,2007,18(1):69-72. [5] Rowland R L,Latimer P H,Giles J A.Flue-cured tobacco.Ⅰ.Isolation of solanesol,an unsaturated alcohol[J].Journal of the American Chemical Society,1956,78(18):4680-4683. [6] Tayior M A,Fraser P D.Solanesol:Added value from solanaceous waste[J].Phytochemistry,2011,72(11/12):1323-1327. [7] Yan N,Liu Y H,Zhang H B,et al.Solanesol biosynthesis in plants[J].Molecules,2017,22(4):1-10. [8] Rao R N,Talluri M V N K,Krishna T S V N M,et al.Continuous counter current extraction,isolation and determination of solanesol in Nicotiana tobacum L.by non-aqueous reversed phase high performance liquid chromatography[J].J Pharm Biomed Anal,2008,46(2):310-315. [9] Wang Y,Gu W.Study on supercritical fluid extraction of solanesol from industrial tobacco waste[J].The Journal of Supercritical Fluids,2018,138:228-237. [10] 张歆,倪晋仁,黄文.超临界CO2萃取烟草中茄尼醇[J].精细化工,2006,23(5):480-482. [11] 孙银合,黄仁亮,邢肖肖,等.氨浸预处理法辅助提取烟草中茄尼醇[J].精细化工,2013,30(1):32-35 [12] Chamberlain W J,Schlotzhauer W S,Chortyk O T.Chemical composition of nonsmoking tobacco products[J].Journal of Agricultural and Food Chemistry,1988,36(1):48-50. [13] 林军,顾正桂,苏复,等.溶剂连续循环萃取法提取烟叶中茄尼醇[J].化学工程,2009,37(2):1-3. [14] Tang D S,Zhang L,Chen H L,et al.Extraction and purification of solanesol from tobacco:(Ⅰ)Extraction and silica gel column chromatography separation of solanesol[J].Separation & Purification Technology,2007,56(3):291-295. [15] Schoitzhauer W S,Severson R F,Chortyk O T,et al.Pyrolytic formation of polynuclear aromatic hydrocarbons from petroleum ether extractable constituents of flue-cured tobacco leaf[J].Journal of Agricultural and Food Chemistry,1976,24(5):992-997. [16] 姚文,武荣成,栾和林.SOT溶剂体系从烟渣中萃取茄尼醇的研究[J].矿冶,1995(4):93-96. [17] Yang M,Gu Z G.Study on technic condition of extracting solanesol from abandon tobacco[J].Advanced Materials Research,2012,550/553:1623-1628. [18] Venkat E,Kothandaraman S,Venkat E,et al.Supercritical fluid methods[J].Methods in Biotechnology,1998,4:91-109. [19] Grosso C,Coelho J P,Pessoa F L P,et al.Mathematical modelling of supercritical CO2 extraction of volatile oils from aromatic plants[J].Chemical Engineering Science,2010,65(11):3579-3590. [20] Eckert C A,Knutson B L,Debenedetti P G.Supercritical fluids as solvents for chemical and materials processing[J].Nature,1996,383(6598):313-318. [21] Huang W,Li Z,Niu H,et al.Bioactivity of solanesol extracted from tobacco leaves with carbon dioxide-ethanol fluids[J].Biochemical Engineering Journal,2008,42(1):92-96. [22] Ruiz-Rodriguez A,Bronze M R,Ponte M N D.Supercritical fluid extraction of tobacco leaves:A preliminary study on the extraction of solanesol[J].Journal of Supercritical Fluids,2008,45(2):171-176. [23] Tiwari B K.Ultrasound:A clean,green extraction technology[J].Trac Trends in Analytical Chemistry,2015,71:100-109. [24] Martinez-Patin O J C,Gull'on B,Romero I,et al.Optimization of ultrasound-assisted extraction of biomass from olive trees using response surface methodology[J].Ultrasonics Sonochemistry,2019,51:487-495. [25] Chen J,Liu X,Xu X,et al.Rapid determination of total solanesol in tobacco leaf by ultrasound-assisted extraction with RP-HPLC and ESI-TOF/MS[J].Journal of Pharmaceutical and Biomedical Analysis,2007,43(3):879-885. [26] 张艺,王刚,陈振斌,等.烟叶中茄尼醇的超声提取及纯化工艺研究[J].中国药房,2016,27(7):932-935. [27] Kaufmann B,Christen P.Recent extraction techniques for natural products:Microwave-assisted extraction and pressurized solvent extraction[J].Phytochemical Analysis,2002,13(2):105-113. [28] Zhou H Y,Liu C Z.Microwave-assisted extraction of solanesol from tobacco leaves[J].Journal of Chromatography A,2006,1129(1):135-139. [29] Zhou H Y,Liu C Z.Rapid determination of solanesol in tobacco by high-performance liquid chromatography with evaporative light scattering detection following microwave-assisted extraction[J].Journal of Chromatography B,2006,835(1/2):119-122. [30] Tang D S,Liang H L,Zhang L,et al.Solid phase extraction of solanesol[J].Chromatographia,2007,66(1/2):129-131. [31] Zhao C,Zu Y,Li C.Extraction of solanesol from tobacco (Nicotiana tobaccum L.) leaves by bubble column[J].Chemical Engineering and Processing,2009,48(1):203-208. [32] 祖元刚,赵春建,李春英,等.鲜法匀浆萃取烟叶中茄尼醇的研究[J].高校化学工程学报,2005,19(6):757-761. [33] Gu M J.Experimental study of refining solanesol from crude solanesol by saponification[J].Computers and Applied Chemistry,2008,2(4):53-56. [34] 赵春建,杨磊,祖元刚,等.动态皂化萃取法提取茄尼醇的研究[J].化学工程,2007,35(9):9-12. [35] 钱超,张坚国,陈新志.分子蒸馏技术提纯茄尼醇的工艺研究[J].高校化学工程学报,2009,23(2):275-278. [36] Gu Z,Ge X,Liu L,et al.A new method of extraction and purification of solanesol from tobacco extracts[C]//2013 International Conference on Materials for Renewable Energy and Environment.IEEE,2014:938-941. [37] Hu R S,Wang J,Li H,et al.Simultaneous extraction of nicotine and solanesol from waste tobacco materials by the column chromatographic extraction method and their separation and purification[J].Separation and Purification Technology,2015,146:1-7. [38] Guo C,Qiao J,Zhang S,et al.Purification of polyphenols from kiwi fruit peel extracts using macroporous resins and high-performance liquid chromatography analysis[J].International Journal of Food Science & Technology,2018,53:1486-1493. [39] Du X,Yuan Q,Li Y.Equilibrium,thermodynamics and breakthrough studies for adsorption of solanesol onto macroporous resins[J].Chemical Engineering and Processing,2008,47(8):1420-1427. [40] Du X L,Yuan Q P,Li Y,et al.Preparative purification of solanesol from tobacco leaf extracts by macroporous resins[J].Chemical Engineering & Technology,2008,31(1):87-94. [41] Ito Y,Bowman R L.Countercurrent chromatography:Liquid-liquid partition chromatography without solid support[J].Science,1970,167(3916):281-283. [42] Hu R,Pan Y.Recent trends in counter-current chromatography[J].Trends in Analytical Chemistry,2012,40:15-27. [43] Du Q Z,Wang D J,Ito Y.Preparation of Solanesol from a tobacco leaf extract using high speed countercurrent chromatography[J].Journal of Liquid Chromatography & Related Technologies,2006,29(17):2587-2592. [44] Zhao Y,Du Q.Separation of solanesol in tobacco leaves extract by slow rotary counter-current chromatography using a novel non-aqueous two-phase solvent system[J].Journal of Chromatography A,2007,1151(1/2):193-196. [45] Davies M P,Biasi V D,Perrett D.Approaches to the rational design of molecularly imprinted polymers[J].Analytica Chimica Acta,2004,504(1):7-14. [46] Ma X,Meng Z,Qiu L,et al.Solanesol extraction from tobacco leaves by flash chromatography based on molecularly imprinted polymers[J].Journal of Chromatography B,2016,1020:1-5. [47] Long J P,Chen Z B,Liu X J,et al.Preparation and adsorption property of solanesol molecular imprinted polymers[J].Designed Monomers and Polymers,2015,18(7):641-649. [48] 王非,郑珩,余永柱,等.高纯度茄尼醇的现状与市场前景[J].现代化工,2005,25(8):63-64,66. [49] 刘项.烟草废弃物提制硫酸烟碱及活性炭的研究[D].重庆:重庆大学,2004. [50] 昆明市环保局.《建设年产100吨茄尼醇生产线项目环境影响报告书》[EB/OL].[2016-06-28].http://hbj.km.gov.cn/c/2016-06-28/2295622.shtml. [51] 田浩,李晚谊,李智敏,等.烟草工业废弃物中提取氨基酸[J].环境工程学报,2012,6(9):3318-3324. [52] Meher K K,Panchwagh A M,Rangrass S,et al.Biomethanation of tobacco waste[J].Environmental Pollution,1995,90(2):199-202.