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现代化工  2018, Vol. 38 Issue (7): 167-171    DOI: 10.16606/j.cnki.issn0253-4320.2018.07.038
  科研与开发 本期目录 | 过刊浏览 | 高级检索 |
响应曲面法优化中空介孔羟基磷灰石负载姜黄素的处方工艺
于蒙蒙1, 王海媛2, 张坚1, 肖学凤1, 晋兴华2
1. 天津中医药大学, 天津 300193;
2. 天津大学药物科学与技术学院, 天津 300072
Optimization of formulation process for curcumin-loading hollow mesoporous hydroxyapatite by response surface methodology
YU Meng-meng1, WANG Hai-yuan2, ZHANG Jian1, XIAO Xue-feng1, JIN Xing-hua2
1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
2. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
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摘要 以碳酸钙为模板,在140℃、碱性水溶液中制备出球形度良好且粒度均匀的中空介孔羟基磷灰石微球,并采用溶剂浸渍法负载上模型药物姜黄素,利用扫描电子显微镜、透射电子显微镜、氮气吸附-解吸附、傅里叶变换红外光谱等仪器对微球及其载药体系进行表征。通过三因素三水平的Box-Behnken实验设计(BBD)对微球包载姜黄素的工艺处方进行优化。研究发现,当姜黄素/HMAPs质量比为19.95:1、载药时间为5.8 h、超声时间为1.48 h时为最优处方工艺,此时载药量理论预测值为73.43%。
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于蒙蒙
王海媛
张坚
肖学凤
晋兴华
关键词:  中空介孔羟基磷灰石微球  姜黄素  Box-Behnken实验设计    
Abstract: Using calcium carbonate as a template,hollow mesoporous hydroxyapatite microspheres (HMAPs) with good sphericity and uniform particle size are synthesized in an alkaline aqueous solution at 140℃,and are loaded with the model drug curcumin by solvent impregnation method.The synthesized HMAPs and its drug-loading system are characterized by scanning electron microscope,transmission electron microscopy,nitrogen adsorption-desorption analysis and Fourier transform infrared spectrometer.The experiments for encapsulation of curcumin by HMAPS are designed and optimized according to a three-level and three-variable Box-Behnken design (BBD),in which three variables include the mass ratio of curcumin/HMAPs,the loading time for drug and the serving time of ultrasonic.The optimal formulation parameters obtained are as follows:the mass ratio of curcumin/HMAPs,the loading time for drug and the serving time of ultrasonic are 19.95:1,5.8 h and 1.48 h,respectively.Under optimal parameters,the theoretical prediction value of drug loading amount is 73.43%.
Key words:  hollow mesoporous hydroxyapatite microspheres    curcumin    Box-Behnken experiment design
收稿日期:  2017-12-04      修回日期:  2018-05-14           出版日期:  2018-07-20
R944.9  
通讯作者:  肖学凤(1966-),女,博士,教授,研究方向为药理方向,通讯联系人,kai1219@163.com;晋兴华(1977-),男,博士,高级工程师,研究方向为载体材料,通讯联系人,15822534131@163.com。    E-mail:  kai1219@163.com;15822534131@163.com
作者简介:  于蒙蒙(1992-),女,硕士研究生,研究方向为中药成分的载体材料,ymm3376@163.com
引用本文:    
于蒙蒙, 王海媛, 张坚, 肖学凤, 晋兴华. 响应曲面法优化中空介孔羟基磷灰石负载姜黄素的处方工艺[J]. 现代化工, 2018, 38(7): 167-171.
YU Meng-meng, WANG Hai-yuan, ZHANG Jian, XIAO Xue-feng, JIN Xing-hua. Optimization of formulation process for curcumin-loading hollow mesoporous hydroxyapatite by response surface methodology. Modern Chemical Industry, 2018, 38(7): 167-171.
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http://www.xdhg.com.cn/CN/10.16606/j.cnki.issn0253-4320.2018.07.038  或          http://www.xdhg.com.cn/CN/Y2018/V38/I7/167
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