Optimization of formulation process for curcumin-loading hollow mesoporous hydroxyapatite by response surface methodology
YU Meng-meng1, WANG Hai-yuan2, ZHANG Jian1, XIAO Xue-feng1, JIN Xing-hua2
1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; 2. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Abstract: Using calcium carbonate as a template,hollow mesoporous hydroxyapatite microspheres (HMAPs) with good sphericity and uniform particle size are synthesized in an alkaline aqueous solution at 140℃,and are loaded with the model drug curcumin by solvent impregnation method.The synthesized HMAPs and its drug-loading system are characterized by scanning electron microscope,transmission electron microscopy,nitrogen adsorption-desorption analysis and Fourier transform infrared spectrometer.The experiments for encapsulation of curcumin by HMAPS are designed and optimized according to a three-level and three-variable Box-Behnken design (BBD),in which three variables include the mass ratio of curcumin/HMAPs,the loading time for drug and the serving time of ultrasonic.The optimal formulation parameters obtained are as follows:the mass ratio of curcumin/HMAPs,the loading time for drug and the serving time of ultrasonic are 19.95:1,5.8 h and 1.48 h,respectively.Under optimal parameters,the theoretical prediction value of drug loading amount is 73.43%.
于蒙蒙, 王海媛, 张坚, 肖学凤, 晋兴华. 响应曲面法优化中空介孔羟基磷灰石负载姜黄素的处方工艺[J]. 现代化工, 2018, 38(7): 167-171.
YU Meng-meng, WANG Hai-yuan, ZHANG Jian, XIAO Xue-feng, JIN Xing-hua. Optimization of formulation process for curcumin-loading hollow mesoporous hydroxyapatite by response surface methodology. Modern Chemical Industry, 2018, 38(7): 167-171.
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