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现代化工  2018, Vol. 38 Issue (7): 128-131    DOI: 10.16606/j.cnki.issn0253-4320.2018.07.029
  科研与开发 本期目录 | 过刊浏览 | 高级检索 |
生物素化果胶纳米粒作为药物载体的研究
赵峰, 刘举慧, 郭建峰
中北大学化学工程与技术学院, 化工综合国家级实验教学示范中心, 山西 太原 030051
Study on biotinylated pectin nanoparticles as pharmaceutical carrier
ZHAO Feng, LIU Ju-hui, GUO Jian-feng
College of Chemical Engineering and Technical, North University of China, National Demonstration Center for Experimental Chemical Engineering Comprehensive, Taiyuan 030051, China
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摘要 合成了生物素化果胶衍生物并通过乳化超声法制备了纳米粒子;以目标药物阿霉素为研究对象,考察了不同条件下纳米粒子包封率和载药量的变化情况。通过红外光谱仪和元素分析仪对生物素化果胶粒子的化学组成及结构进行了表征;用粒度分析仪和扫描电子显微镜分析了生物素化果胶粒子的形貌和尺寸;通过紫外分光光度计确定了生物素化果胶粒子的包封率和载药量。结果表明,合成的生物素化果胶纳米粒呈现较规则的球形结构,粒度分布较均一,平均粒径为(190.2±37.0) nm,生物素取代度为37%,包封率为(84.58±0.78)%,载药量为(12.69±0.37)%。
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赵峰
刘举慧
郭建峰
关键词:  果胶  生物素  阿霉素  药物载体  纳米粒    
Abstract: In this paper,biotinylated pectin derivatives were synthesized and nanoparticles were prepared by emulsification ultrasound method.The target drug doxorubicin was selected as the research object to investigate the change of encapsulation efficiency and drug loading of the nanoparticles under different conditions and provide a basis for further study of the drug as a carrier.The chemical composition and structure of biotinylated pectin particles were confirmed by infrared spectroscopy (FTIR) and elemental analysis.The morphology and size of biotinylated pectin particles were analyzed by particle size analyzer and scanning electron microscope (SEM).The encapsulation efficiency and drug loading of biotinylated pectin particles were determined by UV spectrophotometer.The results showed that the synthesized biotinylated pectin nanoparticles showed a more regular spherical structure and the particle size distribution was more uniform.The average particle size was (190.2±37.0) nm,the biotin substitution was 37%,the encapsulation efficiency was (84.58±0.78)% and the drug loading was (12.69±0.37) wt%.
Key words:  pectin    biotin    adriamycin    pharmaceutical carrier    nanoparticles
收稿日期:  2017-12-07      修回日期:  2018-05-13           出版日期:  2018-07-20
O631  
基金资助: 山西省重点研发计划项目(201603D121022)
通讯作者:  郭建峰(1975-),男,博士,副教授,研究方向为功能高分子材料,通讯联系人,jianfengguo@nuc.edu.cn。    E-mail:  jianfengguo@nuc.edu.cn
作者简介:  赵峰(1994-),男,硕士研究生,研究方向为功能高分子材料,1462531784@qq.com
引用本文:    
赵峰, 刘举慧, 郭建峰. 生物素化果胶纳米粒作为药物载体的研究[J]. 现代化工, 2018, 38(7): 128-131.
ZHAO Feng, LIU Ju-hui, GUO Jian-feng. Study on biotinylated pectin nanoparticles as pharmaceutical carrier. Modern Chemical Industry, 2018, 38(7): 128-131.
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http://www.xdhg.com.cn/CN/10.16606/j.cnki.issn0253-4320.2018.07.029  或          http://www.xdhg.com.cn/CN/Y2018/V38/I7/128
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