Abstract: In this paper,biotinylated pectin derivatives were synthesized and nanoparticles were prepared by emulsification ultrasound method.The target drug doxorubicin was selected as the research object to investigate the change of encapsulation efficiency and drug loading of the nanoparticles under different conditions and provide a basis for further study of the drug as a carrier.The chemical composition and structure of biotinylated pectin particles were confirmed by infrared spectroscopy (FTIR) and elemental analysis.The morphology and size of biotinylated pectin particles were analyzed by particle size analyzer and scanning electron microscope (SEM).The encapsulation efficiency and drug loading of biotinylated pectin particles were determined by UV spectrophotometer.The results showed that the synthesized biotinylated pectin nanoparticles showed a more regular spherical structure and the particle size distribution was more uniform.The average particle size was (190.2±37.0) nm,the biotin substitution was 37%,the encapsulation efficiency was (84.58±0.78)% and the drug loading was (12.69±0.37) wt%.
赵峰, 刘举慧, 郭建峰. 生物素化果胶纳米粒作为药物载体的研究[J]. 现代化工, 2018, 38(7): 128-131.
ZHAO Feng, LIU Ju-hui, GUO Jian-feng. Study on biotinylated pectin nanoparticles as pharmaceutical carrier. Modern Chemical Industry, 2018, 38(7): 128-131.
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