采用超声辅助法制备磁性活性炭复合材料(Fe₃O₄@AC)并用作磁分散固相萃取剂,同时与高效液相色谱法联用对甲苯磺酸瑞马唑仑进行了分离分析。实验结果表明,在最佳实验条件下,甲苯磺酸瑞马唑仑浓度与峰面积间呈良好线性关系,线性范围为0.005~1.000 μg/mL,线性相关系数为0.999 5,检出限为3.5 μg/L。以模拟人体尿液作为实际样品进行加标回收验证,加标回收率为86.1 %~106.9 %,相对标准偏差(RSD)在2.9 %~7.2 %之间。

Fe₃O₄@AC,a magnetic activated carbon composite material,is prepared via the ultrasonic assisted method,and used as a magnetic dispersion solid-phase extraction agent.Meanwhile,it is used with high-performance liquid chromatography together to separate and analyze remazolam tosilate.Experimental results indicate that under the optimal experimental conditions,there exists a good linear relationship between the concentration of remazolam tosilate and the peak area in the range of 0.005 to 1.000 μg·mL^-1,the linear correlation coefficient is 0.999 5,and the detection limit is 3.5 μg·L^-1.Taking the simulated human urine as an actual sample for validation,the spiked recovery rate is 86.1 %-106.9 % and the relative standard deviation is between 2.9 %-7.2 %.