以氨基酸、苯甲醛、氢氧化钠、硼氢化钠为原料合成了一系列N-苄基氨基酸类化合物,并选取典型天然氨基酸进行连续N-苄基化反应,考察了缩合反应中苯甲醛摩尔分数、反应温度、停留时间等因素对反应的影响;以及还原反应中硼氢化钠摩尔分数、反应温度、停留时间等因素对反应的影响。对典型案例进行连续和间歇反应结果的对比,结果表明,连续法能大大缩短反应时间、简化操作、提高装备效率与收率,该研究为氨基酸的连续N-苄基化生产应用奠定了理论基础。

A series of N-benzyl amino acid compounds are synthesized by using amino acids,benzaldehyde,sodium hydroxide and sodium borohydride as raw materials.Typical natural amino acids are also selected for continuous N-benzylation.The effects of the molar fraction of benzaldehyde,reaction temperature,residence time,and other factors on the condensation reaction are investigated,and the influences of the molar fraction of sodium borohydride,reaction temperature,residence time and other factors on the reduction reaction are studied.The results of continuous and batch reaction results are compared in typical cases.It is found that the continuous flow method can greatly shorten the reaction time,simplify the operation,and improve the equipment efficiency and yield.This research work lays a theoretical foundation for the continuous N-benzylation production and application of amino acids.

张娇娇(1997-),女,硕士研究生,研究方向为连续流合成工艺,2660448963@qq.com。