采用重量分析法在300.15~324.05 K温度范围内测定对氨基水杨酸在乙醇、正丙醇、异丙醇、正丁醇、异丁醇、丙酮、醋酸甲酯、醋酸乙酯8种纯溶剂中的溶解度。结果显示对氨基水杨酸的溶解度随着温度的升高而单调递增。将实验测定的溶解度数据与6种理论方程(Apelblat、van't Hoff、λh、NRTL、Wilson、UNIQUAC)进行关联,在纯溶剂中关联结果的平均相对误差分别为0.79%、2.36%、2.71%、1.64%、1.72%、1.61%。结果表明,6种热力学模型对对氨基水杨酸的溶解过程都有很好的关联效果,其中Apelblat方程的关联效果最佳。运用汉森溶解度参数分析对氨基水杨酸的溶解行为;采用van't Hoff方程计算对氨基水杨酸溶解过程中溶解焓ΔH_sol、溶解熵ΔS_sol、溶解吉布斯自由能ΔG_sol等热力学参数,结果显示对氨基水杨酸的溶解是一个吸热、非自发的过程。

The solubility of p-aminosalicylic acid in eight kinds of pure solvents,including ethanol,n-propanol,isopropanol,n-butanol,isobutanol,acetone,methyl acetate,and ethyl acetate,is determined by means of gravimetric method in the temperature range of 300.15 K-324.05 K.It is found that the solubility of p-aminosalicylic acid increases monotonically with the increasing temperature.The solubility data obtained from experiments are correlated with six theoretical models (Apelblat,van't Hoff,λh,NRTL,Wilson,UNIQUAC),and the average relative deviation of the correlation results are 0.79%,2.36%,2.71%,1.64%,1.72%,and 1.61%,respectively.The results reveal that all of six models correlate well with the solubility of p-aminosalicylic acid,among which Apelblat equation shows the best correlation effect.Hansen solubility parameters are used to analyze the dissolution behavior of p-aminosalicylic acid.The van't Hoff equation is employed to calculate the dissolution enthalpy ΔH_sol,dissolution entropy ΔS_sol,and dissolution Gibbs free energy ΔG_sol during the dissolution of p-aminosalicylic acid.Results suggest that the dissolution of p-aminosalicylic acid is an endothermic,non-spontaneous process.

李群生(1963-),男,博士,教授,博士生导师,研究方向为流体力学,1456720201@qq.com