传统的骨组织修复材料存在与骨组织界面之间的结合能力差、愈合效果差等问题。目前研究的骨粘附性复合水凝胶具有良好的生物活性、骨传导性、骨诱导性以及生物相容性等特点。以纳米羟基磷灰石(HAp)、还原氧化石墨烯(rGO-T)、单宁酸(TA)和丝素蛋白(SF)为原料制备SF/TA/rGO-T/HAp复合水凝胶。通过红外光谱和X-射线衍射光谱分别对rGO-T、HAp、SF、TA、复合水凝胶的结构进行表征,用扫描电镜表征复合水凝胶的表面形貌;对复合水凝胶的流变性能、力学性能、抗湿粘附性能测试表明,复合水凝胶具有良好的抗湿粘附性、黏弹性和拉伸强度,溶胀性能和降解性能测试表明其适合植入生物体。

Traditional bone tissue repair materials suffer from poor bonding ability and poor healing effect between the interface with bone tissue.The currently developed bone-adherent composite hydrogels have great bioactivity,osteoconductivity and biocompatibility.SF/TA/rGO-T/Hap composite hydrogel is prepared from nano-hydroxyapatite (HAp),reduced graphene oxide (rGO-T),tannic acid (TA) and silk protein (SF).The structure of rGO-T,HAp,SF,TA and composite hydrogel are characterized by infrared spectroscopy and X-ray diffraction spectroscopy,and the surface morphology of composite hydrogel is characterized by scanning electron microscopy.The tests on rheological properties,mechanical properties and anti-wet adhesion properties of composite hydrogel show that the composite hydrogel has good anti-wet adhesion,viscoelasticity and tensile strength.The tests on its swelling properties and degradation properties indicate that it is suitable for implantation into living organisms.

张祖希(1997-),男,硕士研究生,研究方向为超分子型生物医学材料,dqszzzx2012@163.com