异丁烯氯化法是制备重要有机中间体甲基烯丙基氯的主要方法,有效利用该方法的副产物1,2-二氯叔丁烷可以进一步提升该方法的总收率。设计了一种组合式精馏塔进行反应精馏工艺探索,主要考察了进料氢氧化钠浓度、氢氧化钠与1,2-二氯叔丁烷进料比例、进料速率、进料温度、回流比对1,2-二氯叔丁烷消除反应制备甲基烯丙基氯的影响,得到了较佳制备工艺,甲基烯丙基氯的收率大于99.0%。

Isobutene chlorination is the main method to prepare important organic intermediate methylallyl chloride.Total yield of this method can be further improved by effectively using the by-product 1,2-dichlorotert butane.A combined distillation column is designed to explore the reactive rectification process,and investigate the effects of the concentration of sodium hydroxide,the ratio of sodium hydroxide to 1,2-dichlorotertbutane,the feed rate,the feed temperature and the reflux ratio on the elimination reaction of 1,2-dichlorotertbutane for the preparation of methylallyl chloride.A group of better preparation conditions are obtained,under which the yield of methylallyl chloride exceeds 99.0%.

寇然(1992-),男,博士,高级工程师,研究方向为表面活性剂及中间体的合成研究和产业化,2559553600@qq.com