为提高香紫苏内酯的合成效率，采用超声波强化H₂O₂氧化效能并对反应条件进行了优化，同时对反应机理进行了初步探讨。结果表明，相较于传统氧化，超声辅助合成效率提高9%，且缩短反应时间；通过单因素实验考察合成香紫苏内酯的最佳条件为：超声频率为40 kHz、功率为250 W、n_香紫苏醇：n_钨酸钠：n_过氧化氢=100：1：600、超声温度为60℃。超声反应时间为1.5 h时，香紫苏内酯最佳产率为89%。

In order to improve the synthesis efficiency of perilla lactone,ultrasonic wave is utilized to enhance the oxidation efficiency of H₂O₂,the reaction conditions are optimized,and the reaction mechanism is explored.The results show that compared with traditional oxidation method,the synthesis efficiency by ultrasonic enhanced oxidation method is 9% higher and the reaction time is shortened.Through single factor experiment,the optimum conditions for the synthesis of perilla lactone are as follows:ultrasonic frequency is 40 KHZ,ultrasonic power is 250 W,n(perilla alcohol)：n(sodium tungstate)：n(hydrogen peroxide) =100：1：600,and ultrasonic temperature is 60℃.The yield of perilla lactone is 89% after 1.5 h of ultrasonic reaction under the optimum conditions.

刘华秋(1998-),女,硕士研究生,研究方向为天然产物分离提纯,1654488939@qq.com