采用溶胶-凝胶法制备介孔二氧化硅微球（mSiO₂），以羧甲基壳聚糖（CMCS）、N-异丙基丙烯酰胺（NIPAM）和丙烯酰胺（AM）自由基聚合的接枝共聚体对介孔二氧化硅进行功能化改性，制备出具有pH和温度双重响应的介孔二氧化硅纳米药物载体mSiO₂@CMCS/NIPAM/AM。通过SEM、TM、FT-IR等表征手段分析该药物载体的结构性能。结果表明，以盐酸阿霉素（DOX）为模型药物，当pH为7时，DOX的平衡吸附量为94.99 mg/g，载药率为9.05%，包封率为66.59%。对搭载了DOX的药物载体进行释药实验，在pH为5.7、温度43℃时，DOX的累积释放率达到71%。

Mesoporous silica microspheres (mSiO₂) are prepared by sol-gel method,and is modified functionally by graft copolymer among carboxymethyl chitosan (CMCS),N-isopropylacrylamide (NIPAM) and acrylamide (AM) to prepare mesoporous silica drug carrier (mSiO₂@CMCS/NIPAM/AM) with dual response to pH and temperature.The structure and properties of the drug carrier are analyzed by SEM,TM and FT-IR.It is verified that the equilibrium adsorption capacity of doxorubicin hydrochloride is 94.99 mg·g^-1,the drug loading rate reaches 9.05% and the entrapment efficiency reaches 66.59% when doxorubicin hydrochloride is used as the model drug and pH is 7.The cumulative release rate of doxorubicin hydrochloride reaches 71% at pH=5.7 and 43℃.

葛永驰(1998-),男,本科生,研究方向为功能新材料,ycgeaig@qq.com