利用水热法制备金属有机骨架材料MIL-101（Fe），并用作模型药物左旋咪唑的药物递送载体。利用XRD、SEM、TEM、TGA、IR、Zeta电位和N₂吸附解吸等温线对材料进行表征，通过MTT法评价材料的细胞毒性。结果表明，合成的MIL-101（Fe）为八面体结构的晶体，粒径约为1 μm。左旋咪唑质量浓度为5 mg/mL时MIL-101（Fe）载药量为22.20%。左旋咪唑释放研究在模拟肿瘤细胞酸性环境（pH=5.5）和模拟静脉内溶液（pH=7.4）2种不同pH的模拟体液中进行，体外释放72 h的结果表明，pH 5.5时释放率为57.31%，高于pH=7.4时的释放率；体外释放48 h后药物释放量趋于稳定，说明MIL-101（Fe）具有一定的缓释作用，MIL-101（Fe）对MCF-7细胞无毒。

MIL-101(Fe), a metal-organic framework material, is prepared by hydrothermal method and applied as carrier for delivering model drug levamisole.MIL-101(Fe) is characterized by means of XRD, SEM, TEM, TGA, IR, Zeta potential and N₂-adsorption and desorption isotherm, and its cytotoxicity is evaluated by means of MTT method.The results show that the synthesized MIL-101(Fe) is a crystal with an octahedral structure and its particle size is about 1 μm.The drug loading rate of MIL-101(Fe) for levamisole at a concentration of 5 mg·mL^-1 is 22.20%.Studies on release of levamisole from MIL-101(Fe) are performed in two simulated body fluids respectively with different pH values:the simulated the tumor cells acidic environment (pH=5.5) and the simulated intravenous solution (pH=7.4).Vitro release for 72 hours indicates that the release rate reaches 57.31% at pH=5.5, which is higher than that at pH=7.4.The amount of drug released tends to be stable after 48 hours in vitro release, indicating that MIL-101(Fe) has a certain sustained release effect.It is also verified that MIL-101(Fe) is non-toxic to MCF-7 cells.

谷娜(1981-),女,博士,副教授,主要从事水环境污染功能材料研究,824359149@qq.com。