将具有抗菌性能的金属有机骨架(MOF)材料与具有双交联网络结构的聚乙烯醇(PVA)水凝胶相结合,构建了一种具有优良力学性能和抗菌性能的MOF/PVA抗菌水凝胶复合材料。该抗菌水凝胶采用物理与化学双交联的高分子网络结构,可增强水凝胶的力学性能。水凝胶内部结合了含有Ag⁺的MOF(AMOF)颗粒和含有Zn²⁺的MOF颗粒,随着2种MOF颗粒的缓慢降解,水凝胶持续释放的Ag⁺和Zn²⁺对细菌细胞造成物理损伤,实现对革兰氏阴性与阳性细菌生长的有效抑制,抑制率高达99%以上,为新型抗菌水凝胶材料的设计和构建提供了一种新策略。

MOF/PVA antibacterial composite hydrogel is fabricated from dual-crosslinked polyvinyl alcohol (PVA) networks and antibacterial metal-organic frameworks (MOF).The hydrogel employs physically and chemically dual-crosslinked networks for enhanced mechanical performances.Meanwhile,the hydrogel contains Ag⁺-containing MOF (A-MOF) and Zn²⁺-containing MOF (ZMOF) nanoparticles.The hydrogel allows continuous release of Ag⁺ and Zn²⁺ via slow degradation of MOF nanoparticles,which causes physical damage to the bacteria,effectively inhibiting the growth of Gram-negative and Gram-positive bacteria with an inhibition ratio exceeding 99%.This work provides a new strategy for design and fabrication of novel antibacterial hydrogel materials.

赵宁(1995-),女,硕士研究生,研究方向为化工新材料,Zning925@163.com