以钼酸钠、硫脲、柠檬酸及PEG-400为原料，通过水热法制备纳米MoS₂，考察了材料的光热转换性能及其对阿霉素（DOX）的负载及控释性能，并探讨了该载药体系对癌细胞的光热-化疗协同治疗作用。结果表明，通过该水热反应体系制备的尺寸约500 nm花球状MoS₂纳米材料具有良好的光热转换性能，对DOX的负载率可以达到136.8%，且其释药行为具有pH响应性，pH=5.8时DOX的累积释放量达到70.29%，约为pH=7.4条件下的7倍，表明该材料在药物负载/控释方面具有一定应用价值。此外，负载DOX后的MoS₂-DOX的纳米复合物在近红外光照射下对肝癌细胞HuH-7的抑制率高达92.09%，抑制效果明显高于单一的光热治疗和化疗。

Flower-like MoS₂ nanospheres are prepared via hydrothermal method by using sodium molybdate,thiourea,citric acid and PEG-400 as raw materials.The photothermal conversion performance of MoS₂ nanospheres is studied,and the loading and controlled release ability of the nanospheres to doxorubicin (DOX) are evaluated.Photothermal-chemotherapy synergistic therapy effect of the drug delivery system on cancer cells is further explored.It is shown that the as-prepared flower-like MoS₂ nanospheres with a size about 500 nm exhibit excellent photothermal effect.As a carrier,the load rate of the nanospheres to DOX can reach 136.8%,and the drug release behavior shows responsive to pH.As pH=5.8,the cumulative release amount of DOX can reach 70.29%,which is about 7 times of that at pH=7.4,indicating that the material has promising application in drug loading/controlled release.In addition,MoS₂-DOX composites under near infrared laser irradiation can reach 92.09% of inhibition rate to HuH-7 liver cancer cells,which is significantly higher than that of photothermal therapy alone or chemotherapy alone.

廉爽(1998-),女,硕士研究生,研究方向为纳米生物医用材料,2587063618@qq.com