稳定同位素由于其固有的稳定性和安全性，在核技术应用领域中的优势逐渐突显。发展稳定同位素已成为我国产业转型升级的需要，建立一种可靠的稳定同位素分离方法刻不容缓。概述了目前国内外低温精馏技术分离氢、氧、碳稳定同位素的水平，简要介绍了低温精馏工艺在仿真模拟、原料纯化、监测控制等方面需开展的关键技术研究，展望了我国稳定同位素开发的前景和趋势。

Because of its inherent safety and stability, the advantages of stable isotopes in nuclear technology application field have gradually become prominent.The development of stable isotopes has become the need of industrial transformation and upgrading in China.It is urgent to establish a reliable stable method to separate isotopes.Global present level in separating stable isotopes of hydrogen, oxygen, carbon by cryogenic distillation technology is summarized.Achievements on key technologies in the aspects of simulation, raw material purification, monitoring and control of cryogenic distillation process are briefly introduced.The prospects and trends of development of stable isotopes in China are predicted.