合成了具有生物相容性的马来酸酐松香单乙酯和聚乙二醇-马来酸酐松香聚酯，并利用红外、核磁等方法对产物进行表征。采用弹性光散射探讨了聚乙二醇-马来酸酐松香聚酯在不同温度下的结构转变行为及生物相容性。当聚乙二醇-马来酸酐松香聚酯为临界胶束浓度时，升温过程中胶束发生再次聚集；而当质量浓度小于临界胶束浓度时，单根分子链在升温过程中发生聚集和紧缩。分子链的结构转变与聚集皆为温度可逆过程。因此，在分子水平上探讨了分子链的聚集行为与结构转变，为温敏性聚乙二醇-马来酸酐松香聚酯在表面活性与载药领域的应用提供理论基础。

Both maleic anhydride rosin monoethyl ester and polyethylene glycol-maleic anhydride rosin polyester are synthesized, and characterized by infrared, nuclear magnetic and other methods.The structure transition behavior and biocompatibility of polyethylene glycol-maleic anhydride rosin polyester at different temperatures are investigated by means of elastic light scattering.The micelles will re-aggregate during the heating process when the concentration of polyethylene glycol-maleic anhydride rosin polyester locates at the critical micelle concentration.Single molecular chains will aggregate and shrink during the heating process when the concentration of polyethylene glycol-maleic anhydride rosin polyester is below the critical micelle concentration.The structural transformation and aggregation of molecular chains are both temperature-reversible processes.Therefore, the aggregation behavior and structural transformation of molecular chains are discussed at molecular level, which provides a solid theoretical foundation for the application of temperature-sensitive polyethylene glycol-maleic anhydride rosin polyester in the field of surface activity and drug loading.

朱伯明(1996-),男,硕士研究生,研究方向为松香基高分子的制备与自组装,592429349@qq.com