研究设计了一种环己酮氨肟化反应-沉降分离耦合装置，通过TS-1的絮凝沉降解决了TS-1与反应液的分离问题。分别考察了沉降时间、物料摩尔比、反应温度和停留时间对TS-1沉降效率的影响，优化了工艺条件。结果表明，在n（H₂O₂）：n（环己酮）=1.0、n（氨水）：n（环己酮）=1.8、反应温度70℃、沉降时间6.5 min、停留时间70 min时，可以维持反应体系的稳定，TS-1进行正常的沉降分离，此时料液中TS-1质量分数降低至0.438 6‰，环己酮的转化率和环己酮肟的选择性分别达到96.7%和99.6%。

A kind of reaction-separation coupling device is designed for cyclohexanone ammoximation.Separation of TS-1 and reaction liquid is settled through flocculation and sedimentation of TS-1 in this device.The effects of sedimentation time,reactants molar ratio,reaction temperature and residence time on reactant conversion,product selectivity and TS-1 sedimentation efficiency are investigated,and the process conditions are optimized.Ahe conversion of cyclohexanone reaches 96.7%,the selectivity of cyclohexanone oxime reaches 99.6%,and the TS-1 concentration in overflow liquid reduces 0.438 6‰ as n(H₂O₂):n(cyclohexanone)=1.0:1,n(NH₃H₂O):n(cyclohexanone)=1.8:1,reaction temperature maintains at 70℃,residence lasts for 70 min and sedimentation lasts for 6.5 min.