金属有机框架（metal-organic frameworks，MOFs）是由金属离子和有机配体通过自组装形成的具有周期性网状结构的多孔无机-有机杂化材料，具有孔径可调、比表面积大、孔隙率高等特点，因纳米级尺寸和可控性结构，基于MOFs构建的纳米酶受到研究人员的广泛关注。与传统的天然酶相比，该类具有拟酶活性的纳米材料拥有许多优点，如产量高、价格低廉、稳定性好等。介绍了金属有机框架的特点、合成方法以及在生物传感器中的应用研究进展，并对今后的发展进行了展望。

Metal organic frameworks (MOFs) are porous inorganic-organic hybrid materials with a periodic network structure formed by self-assembly of metal ions and organic ligands,and they have adjustable pore size,large specific surface area,and higher porosity.Because of nanometer size and controllable structure,nano enzymes based on MOFs have received extensive attention from researchers.Compared with traditional natural enzymes,this kind of nanomaterials with mimic enzyme activity has many advantages,such as high yield,low price,and good stability.The characteristics and synthesis methods of metal-organic frameworks,and their application progress in biosensors are reviewed,and the future development is expected.

喻昌木(1996-),男,硕士生