The key technologies,innovation and benefits of the award-winning projects of 2020 US (President) Green Chemistry Challenge Award are analyzed and evaluated.Genomatica receives the Greener Synthetic Pathways Award for bio-based butylene glycol project.Merck & Co.receives the Greener Reaction Conditions Award for designing a multifunctional and stereo-selectively assembled ProDrugs catalyst.Johns Manville is the recipient of Designing Greener Chemicals Award for designing a bio-based formaldehyde-free thermoset binder formulation.Small Business Award is won by Vestaron Corporation by the development of SPEAR® bio insecticide.Academic Award is received by Professor Steven Skerlos of the University of Michigan,because he develops Fusion Coolant Systems for Pure-CutTM technology.