PDF (2940K)
摘要
采用溶液聚合法制备魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料。正交试验分析表明,当高岭土质量为丙烯酸质量的20%、聚合温度为80℃、丙烯酸中和度为70%、聚合时间为90 min、丙烯酰胺与丙烯酸质量比为1∶2时,制备得到的魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料的吸蒸馏水倍率最高,为506.2 g/g。以布洛芬为模型药物,研究了魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料对布洛芬的释药性能,结果表明,载药复合材料在pH=7.4的缓冲溶液中的累积释药率明显高于在pH=1.2的溶液中的累积释药率,其对布洛芬的释放机理符合Fickian扩散。红外光谱(FT-IR)分析结果表明,魔芋、丙烯酸、丙烯酰胺、高岭土和布洛芬发生了相互作用,共同参与了接枝聚合反应。
Abstract
Konjac grafted polyacrylic acid-acrylamide/kaolin composite material,a novel superabsorbent composite,is prepared through aqueous solution polymerization method by using konjac glucmannan (KGM),acrylic acid,acrylamide and kaolin as raw materials.The orthogonal test results show that the highest absorbency 506.2 g·g-1 can be given by the composite that is prepared under the following conditions:the mass amount of kaolin is 20% that of acrylic acid,polymerization temperature is set at 80℃,the neutralization degree of acrylic acid is 70%,polymerization time is 90 min and the mass ratio of acrylamide to acrylic acid is 1∶2.Taking ibuprofen as a model drug,the drug releasing properties of the prepared composites are evaluated in the buffer solution with different pH values.The experimental results show that the cumulative drug-releasing rate of the composites in the buffer solution of pH=7.4 is significantly higher than that in the solution of pH=1.2.The release mechanism of the composites to ibuprofen accords with Fickian diffusion.The results via FT-IR spectra show that the interaction happens among konjac glucmannan,acrylic acid,acrylamide,kaolin and ibuprofen,which all participate in the graft polymerization reaction.
关键词
魔芋
/
释药性能
/
布洛芬
/
丙烯酰胺
/
高岭土
Key words
konjac glucmannan
/
drug releasing properties
/
ibuprofen
/
acrylamide
/
kaolin
魔芋接枝丙烯酸-丙烯酰胺/高岭土复合材料的制备及其释药性能[J].
现代化工, 2020, 40(2): 123-127 DOI:10.16606/j.cnki.issn0253-4320.2020.02.026