透明质酸（HA）较短的生物体内停留时间在一定程度上限制了其应用，以1，4-丁二醇二缩水甘油醚（BDDE）为交联剂对HA进行化学改性，制备了HA凝胶，并考察了其力学性能、流变性、溶胀性以及HA凝胶的关节软骨再生性能。结果表明，HA凝胶断裂伸长率为159%，是一种弹性凝胶；其横截面表现出多孔联通结构，孔径在40 μm左右；溶胀性约为凝胶干重的33倍，具有很强的吸水能力。将HA凝胶用于兔子关节软骨缺损修复，8周后发现其能促进关节软骨再生。因此，该工艺制备的HA凝胶有望用于关节软骨缺损修复的生物医用材料。

Hyaluronic acid (HA) can maintain a short residence time in organisms,which limits its application to some extent.HA gel is prepared through modifying HA by 1,4-butanediol diglycidyl ether (BDDE).The mechanical,rheological,swelling and articular cartilage regeneration properties of HA gel are investigated.It is shown that the elongation at break of HA gel is 159%,indicating that it is an elastic gel.HA gel's cross section exhibits a porous but inter-connected morphology,with an average pore size of about 40 μm.HA gel has a strong water absorption capacity with a swelling ratio of 33.When HA gel is used to repair articular cartilage defects in rabbits,it can promote articular cartilage to regenerate after 8 weeks.Therefore,HA gel prepared by this technology is a promising bio medical material for repairing articular cartilage defects.

张勤勤(1993-),女,硕士研究生,研究方向为生物医用材料,1049768225@qq.com