以汉麻籽为原料，采用超声辅助提取汉麻大麻素。以汉麻总酚（TPC）、总黄酮（TF）以及提取率为响应指标，通过响应面法优化超声提取时间、提取功率和甲醇质量分数，以等离子体的铁还原能力（FRAP）评价其抗氧化能力。结果表明，超声辅助提取汉麻多酚和黄酮的最佳工艺条件为：提取时间为15 min、超声功率为149 W、甲醇质量分数为80%。在该条件下TPC为318.05 mg/g、TF为39.11 mg/g、提取率为11.28%、FRAP还原能力为17.84 mmol（AAE）/g；超声辅助提取比无超声处理的各指标均高出2倍多。经HPLC鉴定分离汉麻大麻素主要为大麻素（CBG）和四氢大麻酚（THC）。

Taking hemp seeds as raw material,hemp cannabinoids are extracted by ultrasonic-assisted extraction.Through using total phenol (TPC) and total flavone (TF) of hemp as well as extraction rate as response indicators,and using FRAP experiment to evaluate the anti-oxidation ability of cannabinoids,response surface methodology (RSM) is used to optimize the extraction time,extraction power and methanol concentration for ultrasound-assisted extraction of hemp cannabinoid.The optimization results show that the optimum conditions for the extraction of hemp cannabinoids are as follows:extraction time is 15 min,ultrasonic power is 149 W and methanol concentration is 80%.Under these conditions,TPC and TV contents can reach 318.05 mg GAE·g^-1 and 39.11 mg QE·g^-1 respectively,the extraction rate can reach 11.28% and FRAP reduction ability is 17.84 mmol AAE·g^-1.The indexes of extraction assisted by ultrasound are more than twice that without ultrasound.It is identified by HPLC that hemp cannabinoids composite mainly cannabinoids and tetrahydrogen cannabinoids.