以碳酸钙为模板，在140℃、碱性水溶液中制备出球形度良好且粒度均匀的中空介孔羟基磷灰石微球，并采用溶剂浸渍法负载上模型药物姜黄素，利用扫描电子显微镜、透射电子显微镜、氮气吸附-解吸附、傅里叶变换红外光谱等仪器对微球及其载药体系进行表征。通过三因素三水平的Box-Behnken实验设计（BBD）对微球包载姜黄素的工艺处方进行优化。研究发现，当姜黄素/HMAPs质量比为19.95：1、载药时间为5.8 h、超声时间为1.48 h时为最优处方工艺，此时载药量理论预测值为73.43%。

Using calcium carbonate as a template,hollow mesoporous hydroxyapatite microspheres (HMAPs) with good sphericity and uniform particle size are synthesized in an alkaline aqueous solution at 140℃,and are loaded with the model drug curcumin by solvent impregnation method.The synthesized HMAPs and its drug-loading system are characterized by scanning electron microscope,transmission electron microscopy,nitrogen adsorption-desorption analysis and Fourier transform infrared spectrometer.The experiments for encapsulation of curcumin by HMAPS are designed and optimized according to a three-level and three-variable Box-Behnken design (BBD),in which three variables include the mass ratio of curcumin/HMAPs,the loading time for drug and the serving time of ultrasonic.The optimal formulation parameters obtained are as follows:the mass ratio of curcumin/HMAPs,the loading time for drug and the serving time of ultrasonic are 19.95:1,5.8 h and 1.48 h,respectively.Under optimal parameters,the theoretical prediction value of drug loading amount is 73.43%.

于蒙蒙(1992-),女,硕士研究生,研究方向为中药成分的载体材料,ymm3376@163.com