合成了生物素化果胶衍生物并通过乳化超声法制备了纳米粒子；以目标药物阿霉素为研究对象，考察了不同条件下纳米粒子包封率和载药量的变化情况。通过红外光谱仪和元素分析仪对生物素化果胶粒子的化学组成及结构进行了表征；用粒度分析仪和扫描电子显微镜分析了生物素化果胶粒子的形貌和尺寸；通过紫外分光光度计确定了生物素化果胶粒子的包封率和载药量。结果表明，合成的生物素化果胶纳米粒呈现较规则的球形结构，粒度分布较均一，平均粒径为（190.2±37.0） nm，生物素取代度为37%，包封率为（84.58±0.78）%，载药量为（12.69±0.37）%。

In this paper,biotinylated pectin derivatives were synthesized and nanoparticles were prepared by emulsification ultrasound method.The target drug doxorubicin was selected as the research object to investigate the change of encapsulation efficiency and drug loading of the nanoparticles under different conditions and provide a basis for further study of the drug as a carrier.The chemical composition and structure of biotinylated pectin particles were confirmed by infrared spectroscopy (FTIR) and elemental analysis.The morphology and size of biotinylated pectin particles were analyzed by particle size analyzer and scanning electron microscope (SEM).The encapsulation efficiency and drug loading of biotinylated pectin particles were determined by UV spectrophotometer.The results showed that the synthesized biotinylated pectin nanoparticles showed a more regular spherical structure and the particle size distribution was more uniform.The average particle size was (190.2±37.0) nm,the biotin substitution was 37%,the encapsulation efficiency was (84.58±0.78)% and the drug loading was (12.69±0.37) wt%.

赵峰(1994-),男,硕士研究生,研究方向为功能高分子材料,1462531784@qq.com