利用微通道反应器设计了连续合成2-溴噻吩的新工艺，并分别从反应温度、停留时间、物料配比等方面进行了研究，确定了最佳的工艺合成条件：在n（噻吩）∶n（HBr）∶n（H₂O₂）=1∶1.25∶1.375、反应温度为25℃、停留时间为30 s时，噻吩的转化率为84.3%，选择性为79.9%。与传统间歇釜式工艺相比，微通道反应器工艺的反应时间明显缩短，操作过程安全简便，产品转化率高、选择性好。

The new technology for continuous synthesis of 2-bromothiophene is designed by using microchannel reactor.The influences of reaction temperature,residence time and molar ratios among raw materials on the reaction are observed.The optimum process conditions are as follows:the conversion of thiophene and the selectivity of 2-bromothiophene can reach 84.3% and 79.9%,respectively when n(thiophene)∶n(HBr)∶n(H₂O₂)=1∶1.25∶1.375,reaction temperature is 25℃ and residence time is 30 s.Compared with the traditional batch pot process,the micro-channel reactor exhibits advantages of shorter reaction time,simpler and safer operation process,higher conversion rate and better selectivity.

申志伟(1992-),男,硕士,研究生,研究方向为微通道反应器在有机合成中的应用,shenzhiweityut@163.com