建立了一种快速、准确测定药物中奥扎格雷钠的双波长吸收光谱法。在弱酸性的Tris-盐酸介质中，奥扎格雷钠与维多利亚蓝B反应生成具有2个明显正吸收峰的蓝色离子缔合物，最大正吸收波长位于668 nm，次大正吸收波长位于512 nm，表观摩尔吸光系数（κ）分别为2.14×10⁴ L/（mol·cm）（668 nm）和1.95×10⁴ L/（mol·cm）（512 nm），奥扎格雷钠的质量浓度在0.1~5.0 mg/L范围内服从朗伯-比尔定律。当采用双波长叠加法测定奥扎格雷钠时，其表观摩尔吸光系数（κ）可达4.09×10⁴ L/（mol·cm）。该方法用于市售奥扎格雷钠药物中奥扎格雷钠含量的测定，结果满意。

A new dual wavelength superposition absorption spectrometry is established for determining fast and accurately the content of ozagrel sodium in drug.In weakly acidic Tris-hydrochloric acid media,ozagrel sodium can react with Victoria blue B to form a blue ionic association complex with two obvious positive absorption peaks.The maximum positive absorption wavelength locates at 668 nm and the second largest positive absorption wavelength arises at 512 nm.The apparent molar absorptivities (κ) are 2.14×10⁴ L·(mol·cm)^-1 at 668 nm and 1.95×10⁴ L·(mol·cm)^-1 at 512 nm,respectively.The mass concentration of ozagrel sodium obeys Lombard Beer's law in the definite range of 0.1-5.0 mg·L^-1.When the dual wavelength superposition absorption spectrometry is used to determine the concentration of ozagrel sodium,its apparent molar absorptivity (κ) can be achieved 4.09×10⁴ L·(mol·cm)^-1.Satisfactory results can be obtained when this method is applied to determine the content of ozagrel sodium in commercially available ozagrel sodium-containing medicines.

庞向东(1962-),男,理学学士,副教授,研究方向为分子光谱分析,cspxdfxsch123456@163.com。