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摘要
对明胶进行氨基化改性,同时用京尼平和单宁酸作为交联剂进行交联反应,然后冷冻干燥得到了氨基化明胶海绵。结果表明,该海绵具有丰富的孔状结构以及快速吸水能力,同时能够通过静电相互作用增强与血细胞间的结合能力,使其具有优异的止血性能,为快速止血材料的制备提供了新方法。
Abstract
To prepare hemostatic materials with excellent hemostatic performance,the gelatin is modified through amination,and then cross-linked with tannic acid and genipin as cross-linking agents,followed by freeze-drying to obtain an aminated gelatin sponge.This sponge has a rich porous structure and rapid water absorption capacity.It can also enhance the binding ability with blood cells through electrostatic interactions,exhibiting excellent hemostatic performance,thus providing a new method for the preparation of rapid hemostatic materials.
关键词
止血海绵
/
止血材料
/
单宁酸
/
京尼平
/
氨基化明胶
Key words
hemostatic sponges
/
hemostatic materials
/
tannic acid
/
genipin
/
aminated gelatin
Author summay
朱雨荷(1999-),女,硕士生,研究方向为生物医药材料,13120458566@163.com;巨晓洁(1980-),女,博士,教授,博士生导师,研究方向为药物控释系统,通讯联系人,juxiaojie@scu.edu.cn。
氨基化明胶海绵的制备及其止血性能研究[J].
, 2024, 44(S2): 94-98 DOI:10.16606/j.cnki.issn0253-4320.2024.S2.018
