现代化工

现代化工 ›› 2024, Vol. 44 ›› Issue (S1) : 218-221,225. DOI: 10.16606/j.cnki.issn0253-4320.2024.S1.039

科研与开发

(1R,2S)-2-氟环丙胺对甲苯磺酸盐合成工艺的改进

吕红兵, 邱滔

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Improvement on synthesis process of (1R,2S)-2-fluorocyclopropylamine p-toluenesulfonate

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Received		Published
2024-01-23		2024-09-30
Issue Date	Revised Date
2024-09-14	2024-01-23

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摘要

研究了(1R,2S)-2-氟环丙胺对甲苯磺酸盐的合成工艺。以丁二烯为原料,经过成环、氧化、还原、拆分等反应,设计合成(1S,2S)-2-氟环丙甲酸,通过考察与优化确定了最佳反应条件;进一步制得目标产物(1R,2S)-2-氟环丙胺对甲苯磺酸盐,产物收率达到75%。

Abstract

The synthesis process of (1R,2S)-2-fluorocyclopropylamine p-toluenesulfonate is studied.(1S,2S)-2-fluorocyclopropanecarboxylic acid is synthesized from butadiene through cyclization,oxidation,reduction,resolution,and other reactions,and the optimal reaction conditions are determined.Further,(1R,2S)-2-fluoro-cyclopropylamine p-methanesulfonate,the target product,is obtained with a total yield of 75%.