在促进剂K₂CO₃/TiO₂的作用下,通过二氧化碳的羧基化反应成功地将噻吩转化为2-噻吩甲酸,并优化了合成条件,考察了促进剂K₂CO₃/TiO₂的结构、性质对合成路线的影响。结果表明,K₂CO₃/TiO₂起主要促进作用的为表面无定型K₂CO₃;考虑到产物的热稳定性,反应温度不宜超过300℃;产物在反应刚开始的1 h内大量生成,此后生成速率急速下降。该研究不仅开发了新颖、环保和高效的2-噻吩甲酸合成路线,还拓展了二氧化碳的高效利用途径。

Under the promotion of K₂CO₃/TiO₂,thiophene is successfully converted to 2-thiophenic acid by carboxylation of carbon dioxide.The synthesis conditions are optimized,and the influences of the structure and properties of K₂CO₃/TiO₂ promoter on the synthesis route are evaluated.The results show that the amorphous K₂CO₃ on the surface of K₂CO₃/TiO₂ plays the major promotion role.Considering the thermal stability of the product,the reaction temperature should not exceed 300℃.The product is generated in large quantity within 1 hour at the beginning of the reaction,and the generation rate rapidly decreases thereafter.This study develops a novel,environmentally friendly,and efficient synthesis route for 2-thiophenic acid,and also expands the efficient utilization pathways for carbon dioxide.

姜维佳(1989-),女,硕士,讲师,主要从事药物合成分析和药理等方面的研究,jiangweijia551@sxtcm.edu.cn