丙酮、甲醇和四氢呋喃共沸物是制药行业常见的待分离物系，而萃取精馏是一种分离共沸物的有效方法。通过三元相图分析对氯苯和二甲基亚砜两种萃取剂进行了比较。运用Aspen Plus软件进行流程模拟分析，使用序列优化法、以年度总费用最小为目标对不同分离流程进行模拟优化。通过对不同分离流程进行比较，确定了先使用氯苯、后使用二甲基亚砜为萃取剂的流程为最佳分离流程；相比于先使用二甲基亚砜、后使用氯苯的流程，此流程能耗降低了25.08%，年度总费用降低了25.38%。

Acetone-methanol-tetrahydrofuran azeotrope is a common separation system in the pharmaceutical industry, which can be effectively separated by extractive distillation method.Chlorobenzene and dimethyl sulfoxide are screened as alternative extractants for the separation of acetone-methanol-tetrahydrofuran azeotrope through their ternary phase diagram analysis.Aspen Plus software is employed to carry out process simulation, and different separation processes are optimized by using the sequence optimization method with the objective of minimizing the total annual cost.Through comparing different separation processes, the process that uses chlorobenzene followed by dimethyl sulfoxide as extractant to obtain acetone, methanol and tetrahydrofuran in sequence is determined as the best process.Compared to the process that uses dimethyl sulfoxide followed by chlorobenzene, the best process saves 25.08% of energy consumption and 25.38% of total annual cost.