提出了一种新型绿色多肽合成方法，并成功将该方法应用于水蛭素的二十肽类似物Bivalirudin的合成。以苄氧羰基（Cbz）为氨基保护基，利用钯炭装填柱快速脱去Cbz保护，偶联反应及其后处理在微通道反应器内完成，实现了偶联-后处理-脱保护全体系的连续化。结果表明，相比于传统多肽合成方法，该方法原子经济性高、环境污染小，有望在多肽合成产业中得到更加广泛地应用。

A novel green peptide synthesis method is proposed, and successfully applied to the synthesis of Bivalirudin, an icosapeptide analogue of hirudin.Benzyloxycarbonyl (Cbz) is used as a protecting group for amino, while the protection is rapidly removed in a column packed with Pd/C catalyst.The coupling reaction and its post-treatment are finished in a microchannel reactor via continuous flowing process, which achieves the continuity of the coupling-posttreatment-deprotection system.It is verified that this method shows a higher atom economy and fewer environment pollution than traditional peptide synthesis methods, it is expected to be more widely used in the peptide synthesis industry.

王振炜(1997-),男,硕士生,研究方向为多肽合成,15684736925@163.com