传统的化学动力疗法（Chemodynamic therapy，CDT）往往依靠内源性H₂O₂产生·OH来对抗细菌，但是产生的·OH难以达到对细菌的彻底清除。此外，细菌内部遭受活性氧攻击时会产生大量的还原型谷胱甘肽（Glutathione，GSH），抑制活性氧（ROS）对细菌的杀伤作用，增加清除细菌的难度。因此，设计并开发了一种由氧化石墨烯（Graphene oxide）/二氧化锰（MnO₂）组成的生物异质结（Biological heterojunction，Bio-HJs）平台。在近红外光照射下，Bio-HJs不仅具有光热效应，还能催化H₂O₂与Mn²⁺氧化生成高致死性活性氧；同时，生成的Mn⁴⁺离子可以大量消耗细菌内的谷胱甘肽，破坏其防御系统。细菌实验进一步证实，制得的Bio-HJs具有强大的抗菌能力，可以有效根治细菌感染。

Traditional Chemodynamic Therapy (CDT) often relies on endogenous H₂O₂ to generate ·OH to fight bacteria, but the generated ·OH is difficult to clear bacteria completely.In addition, the bacteria can generate a large amount of reduced glutathione (GSH) when they are attacked by reactive oxygen species, which inhibits the killing effect of reactive oxygen species (ROS) on bacteria and increases the difficulty in removing bacteria.Therefore, a biological heterojunction (Bio-HJs) platform composed of graphene oxide/manganese dioxide (MnO₂) is designed and developed.Under near-infrared irradiation, Bio-HJs have photothermal effects, and also catalyze the oxidation of H₂O₂ and Mn²⁺ to generate highly lethal reactive oxygen species.Meanwhile, the resulted Mn⁴⁺ can deplete glutathione in bacteria in large quantities, disrupting their defense system.It is further verified by bacterial experiments that Bio-HJs have strong antibacterial ability and can effectively cure bacterial infections.

廉晓克(1994-),男,硕士研究生,研究方向为生物抗菌材料,jasonbluk@163.com