以氨基改性介孔二氧化硅纳米粒（MSN）为基质、羧甲基壳聚糖（CMCS）为pH响应单体、3，3'-二硫代二丙酸为偶联剂，构建出一种pH/氧化还原双响应型药物载体MSN@CMCS。通过FT-IR、TGA、SEM、TEM、EDS、XRD、BET和Zeta电位分析载体的结构和性能。以槲皮素（QC）为药物模型，考察纳米粒的吸附和释放能力。吸附性能测试结果表明，MSN@CMCS的平衡吸附量、载药率和包封率分别为133.8 mg/g、11.80%和44.60%。体外释药结果表明，QC@MSN@CMCS在pH为5和GSH浓度为20 mmol/L的环境下药物累积释放率分别为8.29%和13.71%，说明该药物载体具有pH和氧化还原双重响应性，可以实现药物的控制释放。

MSN@CMCS, a pH/redox dual-responsive drug carrier, is constructed by using amino-modified mesoporous silica nanoparticles (MSN) as the matrix, carboxymethyl chitosan (CMCS) as the pH-responsive monomer, and 3, 3'-dithiodipropionic acid as the coupling agent.The structure and properties of the carrier is analyzed by means of FT-IR, TGA, SEM, TEM, EDS, XRD, BET, and zeta potential.Quercetin (QC) is taken as a drug model to investigate the adsorption and release ability of the nanoparticles.It is found through adsorption performance test that the equilibrium adsorption amount, drug loading rate and encapsulation rate of MSN@CMCS are 133.8 mg·g^-1, 11.80% and 44.60%, respectively.The in vitro release results show that the cumulative drug release rate of QC@MSN@CMCS is 8.29% at pH=5 and 13.71% at a GSH concentration of 20 mmol·L^-1, indicating that the carrier has dual responsive to pH and redox, which can achieve controllable drug release.

王新敬(1998-),女,硕士研究生,研究方向为新型医用(药用)载体,w1536953944@163.com。