为了减少血液透析导管表面血栓的形成，并提高其抗凝血性能，使用多巴胺一锅法将多巴胺和锌铵混合溶液通过振荡的方式涂覆到聚氨酯膜表面，构建了一种亲水的多巴胺锌铵（PDA/Zn）涂层。结果表明，PDA/Zn涂层表面均匀，水接触角低于10°。亲水性能有效减少生物医学种植体与人体导管壁组织的摩擦，从而减轻水肿和感染，减轻患者痛苦。此外，PDA/Zn涂层由于具有亲水性和良好的抗凝性能，可有效减少血栓的形成。该研究为新型亲水性抗凝涂层材料提供了新策略。

To reduce the formation of thrombus on the surface of hemodialysis catheter and improve its anticoagulant properties,a hydrophilic polydopamine-zinc ammonium (PDA/Zn) coating is constructed by coating dopamine and zinc ammonium mixed solution on the surface of polyurethane membrane through shaking method via the dopamine one-pot method.Results show that the surface of PDA/Zn coating is uniform with a water contact angle lower than 10°.The hydrophilicity can effectively reduce the friction between biomedical implants and human conduit wall tissues,thereby reducing edema and infection,and relieving the pain of patients.Besides,PDA/Zn coating has good anticoagulant properties due to its hydrophilicity,which can effectively reduce the formation of thrombosis.This research work provides a new strategy for novel hydrophilic anticoagulant coating materials.

王坡(1996-),男,硕士研究生,研究方向为智能材料,18080039354@163.com