海藻酸钙水凝胶纤维在细胞培养、药物释放等生物医学领域具有广阔的应用前景,但传统模具法或静电纺丝法制备水凝胶的效率较低、性能较差。基于微流控技术制备了连续、均一、稳定的海藻酸钙水凝胶纤维,利用电子显微镜观察其形貌和结构,并在流控过程中探究了两相流速、溶液浓度及芯片尺寸等因素对水凝胶纤维性能的影响。结果表明,纤维的尺寸和力学性能都可以利用微流控技术在一定范围内进行灵活高效的调控。

Calcium alginate hydrogel fiber has broad application prospects in biomedical fields such as cell culture and drug release.However,both traditional mold method or electrospinning method for preparation of hydrogel have low efficiency and lead to poor performance of hydrogel.Based on microfluidics,continuous,homogeneous and stable calcium alginate hydrogel fibers are prepared.The morphology and structure of calcium alginate hydrogel fibers are observed by means of electron microscope.The effects of two phases velocities,solution concentration and chip size on the properties of hydrogel fibers are explored in the microfluidics process.Experimental results show that the size and mechanical properties of the fiber can be controlled flexibly and efficiently in a certain range by means of microfluidic technology.

杨君炜(2000-),男,本科生,研究方向为微流控,1148131355@qq.com